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Nature Methods (3)
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Showing 1–6 of 6 results

Advanced filters: Author: Kristofor J. Webb Clear advanced filters

An isothermal shift assay for proteome scale drug-target identification

Ball, Webb et al develop a method to identify drug targets based on quantification of shifts in thermal stability. They show that this proteome-wide isothermal shift assay (iTSA) can be used for target identification in cell lysates and living cells, with improved throughput over existing methods.

Kerri A. Ball
Kristofor J. Webb
William M. Old
ResearchOpen Access14 Feb 2020
Communications Biology

Volume: 3, P: 1-10
Eavesdropping on PTM cross-talk through serial enrichment

Two approaches to serially enrich protein post-translational modifications allow the detection of multiple modifications in a single biological sample using mass spectrometry.

Kristofor Webb
Eric J Bennett
News & Views27 Jun 2013
Nature Methods

Volume: 10, P: 620-621
Digestion and depletion of abundant proteins improves proteomic coverage

Improved mass spectrometry–based detection of low-abundance proteins in complex proteomes is made possible with a method to selectively digest and deplete high-abundance proteins.

Bryan R Fonslow
Benjamin D Stein
John R Yates III
Research01 Jan 2013
Nature Methods

Volume: 10, P: 54-56
Synergistic activation of the insulin receptor via two distinct sites

Through structural and functional analyses, this work defines the molecular mechanisms underlying the activation of the insulin receptor (IR) involving multisite insulin binding, paving the way for the eventual therapeutic intervention for diseases caused by aberrant activation of IR.

Jie Li
Junhee Park
Xiao-chen Bai
Research31 Mar 2022
Nature Structural & Molecular Biology

Volume: 29, P: 357-368
Addendum: Digestion and depletion of abundant proteins improves proteomic coverage

Bryan R Fonslow
Benjamin D Stein
John R Yates III
Amendments and Corrections27 Feb 2014
Nature Methods

Volume: 11, P: 347-348
Identification of Urine Metabolites as Biomarkers of Early Lyme Disease

Adoracion Pegalajar-Jurado
Bryna L. Fitzgerald
Claudia R. Molins
ResearchOpen Access15 Aug 2018
Scientific Reports

Volume: 8, P: 1-12