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Showing 1–5 of 5 results
Advanced filters: Author: Kristy M. Heppner Clear advanced filters

  • The murine G protein-coupled receptor 83 (Gpr83) is expressed widely in the brain, but its physiological role is largely unknown. Here Müller et al.show that Gpr83 regulates systemic energy metabolism in part by modulating ghrelin signalling in the arcuate nucleus of the hypothalamus.

    • Timo D. Müller
    • Anne Müller
    • Matthias H. Tschöp
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-8

  • Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.

    • Dhiraj G. Kabra
    • Katrin Pfuhlmann
    • Paul T. Pfluger
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via protection against bile acid toxicity.

    • Nadejda Bozadjieva-Kramer
    • Jae Hoon Shin
    • Randy J. Seeley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • The diabetogenic effect of glucagon has long overshadowed the potential of this pancreatic hormone as an endogenous satiety and anti-obesity factor. This Review discusses the role of glucagon as a beneficial endocrine factor in lipid and energy metabolism and its potential as a therapeutic agent on the basis of studies that combine the agonism of glucagon receptor and glucagon-like peptide 1 receptor.

    • Kirk M. Habegger
    • Kristy M. Heppner
    • Matthias H. Tschöp
    Reviews
    Nature Reviews Endocrinology
    Volume: 6, P: 689-697