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Showing 1–4 of 4 results
Advanced filters: Author: Krysten A. Jones Clear advanced filters

  • Many diseases are driven by the insufficient expression of critical genes, but few technologies are capable of rescuing these endogenous protein levels. Here, Cao et al. present an RNA-based technology that boosts protein production from endogenous mRNAs by upregulating their translation.

    • Yang Cao
    • Huachun Liu
    • Bryan C. Dickinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • RNA base-editors are often used in methods for RNA binding protein (RBP) target discovery. Here the authors present a new RBP target discovery method, PRINTER, and suggest optimal RNA base-editors for dual-RBP studies, emphasizing the importance of matching rBEs’ editing biases with RBPs’ binding preferences.

    • Hugo C. Medina-Munoz
    • Eric Kofman
    • Gene W. Yeo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bound inhibitors, which is of interest for further structure-based drug design efforts.

    • Jerzy Osipiuk
    • Saara-Anne Azizi
    • Andrzej Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9