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An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization

Despite their essentiality, human ANP32A and ANP32B are redundant host factors for influenza virus genome replication. In this work, authors show that an influenza virus grown in cells lacking ANP32A and ANP32B evolved to use ANP32E. They explore the polymerase mutations that enable this, and demonstrate increased virulence in mice.

Carol M. Sheppard
Daniel H. Goldhill
Wendy S. Barclay
ResearchOpen Access10 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Creating resistance to avian influenza infection through genome editing of the ANP32 gene family

In chickens, influenza A virus relies on host protein ANP32A. Here the authors use CRISPR/Cas9 to generate homozygous gene edited chickens containing two ANP32A amino acid substitutions that prevent viral polymerase interaction.

Alewo Idoko-Akoh
Daniel H. Goldhill
Mike J. McGrew
ResearchOpen Access10 Oct 2023
Nature Communications

Volume: 14, P: 1-15
SARS-CoV-2 variants retain high airborne transmissibility by different strategies

Jie Zhou
Ksenia Sukhova
Wendy S. Barclay
ResearchOpen Access01 May 2025
npj Viruses

Volume: 3, P: 1-9
Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Certain bats species have previously been identified as ancestral sources of coronaviruses that infect humans but there is limited data on the genomic diversity or zoonotic potential of viruses infecting bats in the UK. Here, the authors use deep sequencing and in vitro assays to characterise coronaviruses recovered from 48 bat faecal samples.

Cedric C. S. Tan
Jahcub Trew
Vincent Savolainen
ResearchOpen Access27 Jun 2023
Nature Communications

Volume: 14, P: 1-13
The global H5N1 influenza panzootic in mammals

This Perspective reviews the molecular and ecological factors that have driven the expansion in geographical distribution and host species range of H5N1 avian influenza viruses, leading to the current panzootic.

Thomas P. Peacock
Louise Moncla
Martha I. Nelson
Reviews24 Sept 2024
Nature

Volume: 637, P: 304-313

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An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization

Creating resistance to avian influenza infection through genome editing of the ANP32 gene family

SARS-CoV-2 variants retain high airborne transmissibility by different strategies

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

The global H5N1 influenza panzootic in mammals

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