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Showing 1–2 of 2 results
Advanced filters: Author: Kseniya Obraztsova Clear advanced filters

  • The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-operative dysregulation of mTORC1 and WNT growth pathways in the sex- and age-specific changes leading to structural and functional decline.

    • Kseniya Obraztsova
    • Maria C. Basil
    • Vera P. Krymskaya
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • In E. coli, disruption of TopoI and RNAP interaction decreases cells viability and leads to hypernegative DNA supercoiling and R loops accumulation. TopoI and DNA gyrase bind around transcription units and TopoI recognizes cleavage sites by a specific motif and negative supercoiling.

    • Dmitry Sutormin
    • Alina Galivondzhyan
    • Konstantin Severinov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19