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Correction: Corrigendum: Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Alexander Adibekian
Brent R Martin
Benjamin F Cravatt
Amendments and Corrections15 Feb 2012
Nature Chemical Biology

Volume: 8, P: 318
Chemoproteomic capture of RNA binding activity in living cells

Here the authors introduce a photo-activatable-competition and chemoproteomic enrichment (PACCE) method to localize protein-RNA interfaces using photoactivatable cellular RNA to protect RNA binding regions on proteins from electrophilic purine probe labeling.

Andrew J. Heindel
Jeffrey W. Brulet
Ku-Lung Hsu
ResearchOpen Access07 Oct 2023
Nature Communications

Volume: 14, P: 1-14
Analyzing the dynamic bacterial glycome with a lectin microarray approach

Ku-Lung Hsu
Kanoelani T Pilobello
Lara K Mahal
Research05 Feb 2006
Nature Chemical Biology

Volume: 2, P: 153-157
Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering

A chemoproteomics and protein engineering strategy to investigate metabolic activity of lipid kinases led to assignment of a key role for atypical C1 domains in directing fatty acyl specificity of diacylglycerol kinase function in live cells.

Timothy B. Ware
Caroline E. Franks
Ku-Lung Hsu
Research13 Jan 2020
Nature Chemical Biology

Volume: 16, P: 170-178
Global targeting of functional tyrosines using sulfur-triazole exchange chemistry

Sulfur-triazole exchange (SuTEx) chemistry is a tunable platform for covalent chemoproteomic probes that selectively target tyrosines, used to identify residues with enhanced nucleophilicity and monitor activation of phosphotyrosine sites.

Heung Sik Hahm
Emmanuel K. Toroitich
Ku-Lung Hsu
Research25 Nov 2019
Nature Chemical Biology

Volume: 16, P: 150-159
Catch your breath

Carbon dioxide (CO₂) is a product of cellular respiration that can also serve as a post-translational modification (PTM) through covalent protein modification. A new chemoproteomic strategy enables the capture of functional CO₂-dependent carboxylation on lysine residues of proteins.

R. Justin Grams
Ku-Lung Hsu
News & Views16 Jun 2022
Nature Chemical Biology

Volume: 18, P: 686-687
DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

Potent, selective inhibitors reveal that DAGLβ is a principal 2-AG biosynthetic enzyme and regulates inflammatory processes in mouse peritoneal macrophages.

Ku-Lung Hsu
Katsunori Tsuboi
Benjamin F Cravatt
Research28 Oct 2012
Nature Chemical Biology

Volume: 8, P: 999-1007
Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Investigations of serine hydrolases have been frustrated by a lack of selective chemical inhibitors. Profiling of synthetically accessible 1,2,3-triazole ureas in cells and mice now identifies several effective compounds, application of which yields new insights into N-acetylation by APEH.

Alexander Adibekian
Brent R Martin
Benjamin F Cravatt
Research15 May 2011
Nature Chemical Biology

Volume: 7, P: 469-478
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Phenotypic screening for serine hydrolase inhibitors capable of modulating lipid storage coupled with target deconvolution identifies carboxylesterase 3 as having a role in regulating adipocyte function, with enzyme inhibition causing positive outcomes in mouse models of obesity and diabetes.

Eduardo Dominguez
Andrea Galmozzi
Enrique Saez
Research22 Dec 2013
Nature Chemical Biology

Volume: 10, P: 113-121
A lectin microarray approach for the rapid analysis of bacterial glycans

Ku-Lung Hsu
Lara K Mahal
Protocols27 Jun 2006
Nature Protocols

Volume: 1, P: 543-549

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Correction: Corrigendum: Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Chemoproteomic capture of RNA binding activity in living cells

Analyzing the dynamic bacterial glycome with a lectin microarray approach

Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering

Global targeting of functional tyrosines using sulfur-triazole exchange chemistry

Catch your breath

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

A lectin microarray approach for the rapid analysis of bacterial glycans

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