The previously unknown human prenyltransferase, GGTase3, geranylgeranylates the ubiquitin ligase FBXL2, which bears a motif predicted to be recognized by GGTase1. The structure of the GGTase3–FBXL2–SKP1 complex reveals the basis of GGTase3 substrate specificity.
- Shafi Kuchay
- Hui Wang
- Michele Pagano