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Boström et al. reply

Pontus Boström
Jun Wu
Bruce M. Spiegelman
Research29 Aug 2012
Nature

Volume: 488, P: E10-E11
Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

During starvation, muscle strength and endurance, are still critical for survival. Seven days of complete fasting did not reduce maximal strength in leg muscles, but maximal endurance capacity was decreased because carbohydrate oxidation was restrained.

Kristoffer J. Kolnes
Emelie T. F. Nilsen
Jørgen Jensen
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

Alice Williamson
Dougall M. Norris
Claudia Langenberg
Research08 Jun 2023
Nature Genetics

Volume: 55, P: 973-983
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Muscle mass is lost in patients with diabetes, which is associated with mitochondrial disfunction. Here they show that SLIRP maintains muscle mitochondria and that exercise training can compensate for SLIRP loss, improving mitochondrial function and quality control in muscle.

Tang Cam Phung Pham
Steffen Henning Raun
Lykke Sylow
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-21
Personalized phosphoproteomics identifies functional signaling

Functionally relevant phosphorylation sites are detected by integrating phosphoproteomic and phenotypic data.

Elise J. Needham
Janne R. Hingst
Sean J. Humphrey
Research02 Dec 2021
Nature Biotechnology

Volume: 40, P: 576-584
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

In mice, expression of PGC1-α in muscles is shown to stimulate expression of FNDC5, which is cleaved and secreted in the circulation as the newly identified hormone irisin; on exercise, this hormone stimulates browning of subcutaneous adipose tissue.

Pontus Boström
Jun Wu
Bruce M. Spiegelman
Research11 Jan 2012
Nature

Volume: 481, P: 463-468
YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study

Alisa D. Kjaergaard
Allan A. Vaag
Niels Jessen
ResearchOpen Access05 Apr 2025
British Journal of Cancer

Volume: 132, P: 1019-1026
Non-invasive liver fibrosis markers are increased in obese individuals with non-alcoholic fatty liver disease and the metabolic syndrome

Anders Askeland
Rikke Wehner Rasmussen
Aase Handberg
ResearchOpen Access27 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Investigation of the correlation between diabetic retinopathy and prevalent and incident migraine in a national cohort study

Anna Stage Vergmann
Lonny Stokholm
Jakob Grauslund
ResearchOpen Access20 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Michaela Kozakova
Amalia Gastaldelli
Carlo Palombo
Research29 Apr 2020
Journal of Human Hypertension

Volume: 35, P: 334-342

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Boström et al. reply

Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Personalized phosphoproteomics identifies functional signaling

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study

Non-invasive liver fibrosis markers are increased in obese individuals with non-alcoholic fatty liver disease and the metabolic syndrome

Investigation of the correlation between diabetic retinopathy and prevalent and incident migraine in a national cohort study

Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

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