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Showing 1–3 of 3 results
Advanced filters: Author: Kurt Warncke Clear advanced filters

  • Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 by KAT7 and Sirt2 respectively.

    • Guo Chen
    • Yin Luo
    • Xingming Deng
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Naylor et al. systematically review the efficacy of treatments for beta-cell monogenic diabetes. Limited evidence from the mostly non-randomized, small studies supports no treatment in glucokinase-related hyperglycemia and sulfonylureas for HNF1A-diabetes; further evidence is needed on the optimum treatments in these and other monogenic subtypes.

    • Rochelle N. Naylor
    • Kashyap A. Patel
    • Tiinamaija Tuomi
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-17