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Showing 1–3 of 3 results
Advanced filters: Author: Kutay D. Atabay Clear advanced filters

  • Evolutionary eye loss has occurred in multiple phyla in species that inhabit dark environments, but few of those species have been studied thus far. Here they show that cave planarians retain small functional eyes despite their apparent absence, revealing a progenitor depletion mechanism to explain the evolutionary diminution of organ size.

    • Luiza O. Saad
    • Thomas F. Cooke
    • Federico D. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • The developing human cortex contains diverse populations of neural progenitor cells, including a large proportion of outer radial glia (ORG), a progenitor type that is rare in the mouse. The authors identify a transcriptional signature of ORG characterized by markers of neuronal lineage fate and use single-cell analyses to contrast the heterogeneity of cortical progenitors across human, mouse and ferret.

    • Matthew B Johnson
    • Peter P Wang
    • Christopher A Walsh
    Research
    Nature Neuroscience
    Volume: 18, P: 637-646

  • Christopher Walsh and colleagues identify mutations in CHMP1A in human cerebellar hypoplasia and microcephaly. Cells lacking CHMP1A show decreased cell proliferation and decreased expression of BMI1, a negative regulator of stem cell proliferation.

    • Ganeshwaran H Mochida
    • Vijay S Ganesh
    • Christopher A Walsh
    Research
    Nature Genetics
    Volume: 44, P: 1260-1264