The proteasome complexes, composed of 20S core particles and one or two regulatory particles (proteasome activators), degrade most eukaryotic proteins. Here, the authors identify a sequence motif and resolve its interactions mediating the activation of the human 20S proteasome.
- Kwadwo A. Opoku-Nsiah
- Andres H. de la Pena
- Jason E. Gestwicki