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Showing 1–5 of 5 results
Advanced filters: Author: Kyla D. Omilusik Clear advanced filters

  • The invariant chain CD74 is involved in the formation of major histocompatibility complex class II. Jefferies and colleagues show that it also associates with class I in the endolysomal compartment and is important in cross-presentation.

    • Genc Basha
    • Kyla Omilusik
    • Wilfred A Jefferies
    Research
    Nature Immunology
    Volume: 13, P: 237-245

  • Memory T cells protect against previously encountered pathogens, but their origins are unclear. Two studies track DNA modifications over time and find that these cells arise from effector T cells.

    • Kyla D. Omilusik
    • Ananda W. Goldrath
    News & Views
    Nature
    Volume: 552, P: 337-339

  • Activation of CD4+ T cells leads to their polarization to various effector states. Goldrath and colleagues identify a role for the E-protein inhibitor Id2 in promoting TH1 cell polarization over TFH cell polarization. Reciprocally, the transcription factor Bcl-6 represses Id2 expression in TFH cells.

    • Laura A Shaw
    • Simon Bélanger
    • Ananda W Goldrath
    Research
    Nature Immunology
    Volume: 17, P: 834-843

  • The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8+ T cells, providing insights into the signals that promote T cell residency in non-lymphoid tissues and tumours.

    • J. Justin Milner
    • Clara Toma
    • Ananda W. Goldrath
    Research
    Nature
    Volume: 552, P: 253-257