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Showing 1–3 of 3 results
Advanced filters: Author: Kyle F. Biegasiewicz Clear advanced filters

  • Enzymes are powerful catalysts for chemical synthesis because they are capable of providing unparalleled levels of selectivity; however, in nature they only catalyse a limited collection of reactions. Now, it has been shown that non-natural reactions that proceed via free-radical intermediates can be catalysed with high selectivity by using an exogenous photoredox catalyst in conjunction with enzymes.

    • Kyle F. Biegasiewicz
    • Simon J. Cooper
    • Todd K. Hyster
    Research
    Nature Chemistry
    Volume: 10, P: 770-775

  • Flavin-dependent ‘ene’-reductases have now been shown to catalyse redox-neutral radical cyclizations of α-haloamides to form enantioenriched oxindoles. Mechanistic studies indicate the reaction proceeds via the flavin semiquinone/quinone redox couple, where a ground state flavin semiquinone provides the electron for substrate reduction and flavin quinone oxidizes the radical formed after cyclization.

    • Michael J. Black
    • Kyle F. Biegasiewicz
    • Todd K. Hyster
    Research
    Nature Chemistry
    Volume: 12, P: 71-75

  • Enzymes catalyse radical-mediated fluorine atom transfer reactions for enantioselective C(sp3)-F bond formation.

    • Elizabeth J. Gross
    • Kyle F. Biegasiewicz
    News & Views
    Nature Synthesis
    Volume: 3, P: 932-934