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Showing 1–5 of 5 results
Advanced filters: Author: Kyle L. Ferber Clear advanced filters
  • The first-in-human clinical trial of the LRRK2-targeting antisense oligonucleotide BIIB094 in Parkinson’s disease demonstrates that the treatment is well tolerated and produces dose-dependent reductions in cerebrospinal fluid levels of LRRK2 and phosphorylated Rab10, indicating successful target engagement.

    • Omar S. Mabrouk
    • Ben Tichler
    • Danielle L. Graham
    Research
    Nature Medicine
    P: 1-11
  • The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.

    • Benjamin B. Sun
    • Joshua Chiou
    • Christopher D. Whelan
    ResearchOpen Access
    Nature
    Volume: 622, P: 329-338