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Showing 1–4 of 4 results
Advanced filters: Author: Kyle S. McCommis Clear advanced filters

  • Impaired myocardial metabolic flexibility is associated with cardiac dysfunction in diabetes and heart failure. McCommis et al. reveal a critical role for mitochondrial pyruvate use in cardiac function, and use dietary interventions to enhance cardiac fat metabolism in dilated cardiomyopathy.

    • Kyle S. McCommis
    • Attila Kovacs
    • Brian N. Finck
    Research
    Nature Metabolism
    Volume: 2, P: 1232-1247

  • Nanoscale membrane lipid domains are emerging as important regulators of ion channel function. This study highlights their role in modulating pacemaker HCN channels in sensory neurons, revealing a mechanism that may contribute to neuropathic pain.

    • Lucas J. Handlin
    • Natalie L. Macchi
    • Gucan Dai
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Obesity represents a risk factor for cancer and compromises immune function, however the mechanisms linking the two together are not fully known. Here authors show in a mouse sarcoma model that obesity increases tumour incidence, impairs intra-tumoral T cell immunity but paradoxically increases sensitivity to immune therapy via impairing immunoediting.

    • Alexander Piening
    • Emily Ebert
    • Ryan M. Teague
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12