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Showing 1–9 of 9 results
Advanced filters: Author: Kyle Swain Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • The likelihood of severe COVID-19 increases with age upon SARS-CoV-2 infection and even milder disease manifestations might differ among age groups. Here authors show, by immune transcriptome analysis of samples from the upper respiratory tract and peripheral blood of participants from different age groups, that interferon responses are more typical for the young, while activation of myeloid, inflammatory, and coagulation pathways is exclusive to adults.

    • Jillian H. Hurst
    • Aditya A. Mohan
    • Matthew S. Kelly
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Cryo-EM reveals an asymmetric bacterial photosynthetic supercomplex built upon a homodimeric reaction center core. The structure provides mechanistic insights into light excitation transfer and a possible evolutionary transition intermediate of photosynthetic machinery.

    • Ryan Puskar
    • Chloe Du Truong
    • Po-Lin Chiu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

    • Coen M. Adema
    • LaDeana W. Hillier
    • Richard K. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Top-down proteomics can provide unique insights into the biological variations of protein biomarkers but detecting low-abundance proteins in body fluids remains challenging. Here, the authors develop a nanoparticle-based top-down proteomics approach enabling enrichment and detailed analysis of cardiac troponin I in human serum.

    • Timothy N. Tiambeng
    • David S. Roberts
    • Ying Ge
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • HIV-1 infection is associated with persistent inflammation that can contribute to a variety of comorbidities. Luban and colleagues demonstrate that HIV-1 infection results in permanent depletion of innate lymphoid cells, leading to breakdown of gut barrier function and a feed-forward inflammation loop, which includes skewing of NK cells toward an inflammatory/memory phenotype.

    • Yetao Wang
    • Lawrence Lifshitz
    • Jeremy Luban
    Research
    Nature Immunology
    Volume: 21, P: 274-286