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Advanced filters: Author: Kyle Tomsky Clear advanced filters

  • Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus inhibiting metastasis of breast cancer cells.

    • Juan Liu
    • Cen Zhang
    • Zhaohui Feng
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16