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Showing 1–4 of 4 results
Advanced filters: Author: Kyoung-Jae Choi Clear advanced filters

  • KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA binding domain with DNA is enhanced by CpG methylation

    • Rajesh Sharma
    • Kyoung-Jae Choi
    • Josephine C. Ferreon
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Epigenetic regulations of autophagy have emerged as mechanisms for maintaining cellular homeostasis. Here the authors reveal that the CARM1-Pontin-FOXO3a signaling axis can activate autophagy related genes through enhancer activation.

    • Young Suk Yu
    • Hijai R. Shin
    • Sung Hee Baek
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene expression and intestinal homeostasis; IEC-specific HDAC3 deficiency gives rise to Paneth cell abnormalities, impaired intestinal barrier function, and increased DSS-induced intestinal inflammation in commensal-bacteria-containing, but not germ-free, mice.

    • Theresa Alenghat
    • Lisa C. Osborne
    • David Artis
    Research
    Nature
    Volume: 504, P: 153-157