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Showing 1–3 of 3 results
Advanced filters: Author: Kyren A. Lazarus Clear advanced filters

  • BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secretory luminal cell phenotype that occurs in a Brca1 deficient mouse model of breast cancer at early stages of tumour initiation and in breast cells from BRCA1 carriers.

    • Karsten Bach
    • Sara Pensa
    • Walid T. Khaled
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidate for this devastating disease.

    • Kyren A. Lazarus
    • Fazal Hadi
    • Walid T. Khaled
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11