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Inter-chromosomal contacts demarcate genome topology along a spatial gradient

The authors develop a supervised and unsupervised learning algorithm Signature. Machine learning and network model analysis of Hi-C datasets across 62 2n genomes suggest that inter-chromosomal contacts demarcate genome topology along a spatial gradient of genome activity.

Milad Mokhtaridoost
Jordan J. Chalmers
Philipp G. Maass
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-17
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

Experimental work and computational modeling together reveal a suite of catalytic roles of the GlcN6P cofactor in the glmS ribozyme, including activation of the nucleophile, electrostatic stabilization, and alignment of the active site.

Jamie L Bingaman
Sixue Zhang
Philip C Bevilacqua
Research13 Feb 2017
Nature Chemical Biology

Volume: 13, P: 439-445
Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

The concentration of divalent cations is well-known to influence molecular processes such as enzymatic activity and RNA folding. Here the authors attempt to reproduce physiological conditions for RNA folding in vitro and establish an important contribution of chelated magnesium ions in enhancing RNA function.

Ryota Yamagami
Jamie L. Bingaman
Philip C. Bevilacqua
ResearchOpen Access01 Jun 2018
Nature Communications

Volume: 9, P: 1-12
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Rodin and Dou et al. characterized genome-wide somatic mutation in autistic and control brains, revealing that even unaffected individuals may possess dozens of brain somatic mutations and providing insight into the role of somatic mutation in autism.

Rachel E. Rodin
Yanmei Dou
Christopher A. Walsh
Research11 Jan 2021
Nature Neuroscience

Volume: 24, P: 176-185
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

Zhu et al. discover that in human brain there is widespread anatomic distribution of low-frequency somatic, mosaic L1 insertions, using deep whole-genome sequencing of neuronal and glial fractions and machine-learning analysis.

Xiaowei Zhu
Bo Zhou
Alexander E. Urban
Research11 Jan 2021
Nature Neuroscience

Volume: 24, P: 186-196
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Rachel E. Rodin
Yanmei Dou
Christopher A. Walsh
Amendments and Corrections29 Aug 2023
Nature Neuroscience

Volume: 26, P: 1833
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

Xiaowei Zhu
Bo Zhou
Alexander E. Urban
Amendments and Corrections30 Aug 2023
Nature Neuroscience

Volume: 26, P: 1833
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Rachel E. Rodin
Yanmei Dou
Christopher A. Walsh
Amendments and Corrections22 Mar 2021
Nature Neuroscience

Volume: 24, P: 611
Mifepristone in the Central Nucleus of the Amygdala Reduces Yohimbine Stress-Induced Reinstatement of Ethanol-Seeking

Jeffrey A Simms
Carolina L Haass-Koffler
Selena E Bartlett
Research02 Nov 2011
Neuropsychopharmacology

Volume: 37, P: 906-918
Genomic resources for the study of neuropsychiatric disorders

G Senthil
T Dutka
T Lehner
Reviews21 Mar 2017
Molecular Psychiatry

Volume: 22, P: 1659-1663
NIMH neuropsychiatric genomics: crucial foundational accomplishments and the extensive challenges that remain

D L Braff
News26 Sept 2017
Molecular Psychiatry

Volume: 22, P: 1656-1658

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Inter-chromosomal contacts demarcate genome topology along a spatial gradient

The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Mifepristone in the Central Nucleus of the Amygdala Reduces Yohimbine Stress-Induced Reinstatement of Ethanol-Seeking

Genomic resources for the study of neuropsychiatric disorders

NIMH neuropsychiatric genomics: crucial foundational accomplishments and the extensive challenges that remain

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