Nature Search

A molecular assembler

The idea of nanometre-scale machines that can assemble molecules has long been thought of as the stuff of science fiction. Such a machine has now been built — and might herald a new model for organic synthesis. See Letter p.374

T. Ross Kelly
Marc L. Snapper
News & Views21 Sept 2017
Nature

Volume: 549, P: 336-337
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

Janne L. Simonsen
Cecilia Rosada
Moustapha Kassem
Research01 Jun 2002
Nature Biotechnology

Volume: 20, P: 592-596
Neural computation of log likelihood in control of saccadic eye movements

R. H. S. Carpenter
M. L. L. Williams
Research07 Sept 1995
Nature

Volume: 377, P: 59-62
Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism

Secondary bile acids are microbially produced metabolites linked to metabolic diseases. A challenge in microbiota research is to understand how bacteria collaborate to produce such bioactive molecules. Here, the authors show that adding a single low-abundance bacterial species to a community can significantly affect the metabolic output and host physiology.

Annika Wahlström
Ariel Brumbaugh
Fredrik Bäckhed
ResearchOpen Access20 May 2024
Nature Communications

Volume: 15, P: 1-11
Stereodivergent synthesis with a programmable molecular machine

A molecular machine that can be programmed to position a substrate at one of two directing sites on a molecule, which control the stereochemistry of addition to the substrate, demonstrates complexity, precision and function previously only observed in nature.

Salma Kassem
Alan T. L. Lee
Simone Pisano
Research21 Sept 2017
Nature

Volume: 549, P: 374-378
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

A new study shows that Wnt16 inhibits osteoclast formation, suggesting it may be a possible therapeutic option for treating bone fractures in osteoporosis.

Sofia Movérare-Skrtic
Petra Henning
Claes Ohlsson
Research12 Oct 2014
Nature Medicine

Volume: 20, P: 1279-1288
A deep catalogue of protein-coding variation in 983,578 individuals

A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
ResearchOpen Access20 May 2024
Nature

Volume: 631, P: 583-592
Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may be a factor coupling bone resorption to energy metabolism.

Megan M. Weivoda
Chee Kian Chew
Sundeep Khosla
ResearchOpen Access07 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Alexander Rauch
Anders K. Haakonsson
Susanne Mandrup
Amendments and Corrections25 Mar 2019
Nature Genetics

Volume: 51, P: 766
Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Transcriptional and epigenomic profiling of osteoblast and adipocyte differentiation shows that adipogenesis is driven by de novo activation of enhancers, whereas osteogenesis involves preestablished enhancers and depends on the activation of pro-osteogenic and antiadipogenic transcription factors.

Alexander Rauch
Anders K. Haakonsson
Susanne Mandrup
Research04 Mar 2019
Nature Genetics

Volume: 51, P: 716-727
III-Nitride MEMS drum resonators on flexible metal substrates

A. Kassem
R. Gujrati
J. P. Salvestrini
ResearchOpen Access24 Oct 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-13
Long-Term Follow-up of Premature Infants Treated With Prophylactic, Intratracheal Recombinant Human CuZn Superoxide Dismutase

Jonathan M Davis
Susan E Richter
Nadim Kassem
Research29 Jun 2000
Journal of Perinatology

Volume: 20, P: 213-216
Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm

Factory assembly lines often feature robots that pick up, reposition and connect components in a programmed manner. Now, it has been shown that a molecular machine is able to pick up a cargo, reposition it, set it down and release it at a site approximately 2 nm away from the starting position.

Salma Kassem
Alan T. L. Lee
Jordi Solà
Research21 Dec 2015
Nature Chemistry

Volume: 8, P: 138-143
Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder

Fabiana L. Lopes
Kevin Zhu
Francis J. McMahon
ResearchOpen Access24 Aug 2020
Translational Psychiatry

Volume: 10, P: 1-7
Microduplications of 16p11.2 are associated with schizophrenia

Jonathan Sebat and colleagues report the association of microduplication on chromosome 16p11.2 with schizophrenia, while the reciprocal microdeletion was associated with autism and developmental disorders.

Shane E McCarthy
Vladimir Makarov
Jonathan Sebat
Research25 Oct 2009
Nature Genetics

Volume: 41, P: 1223-1227
Twenty-four-Hour Osteocalcin, Carboxyterminal Propeptide of Type I Procollagen, and Aminoterminal Propeptide of Type III Procollagen Rhythms in Normal and Growth-Retarded Children

G Saggese
G I Baroncelli
G Dinero
Research01 Apr 1994
Pediatric Research

Volume: 35, P: 409-415
Safety, quality attributes, and health risk assessments of sand smelt fish

Gehad A. Ezzat
Gehan M.A. Kassem
Nermeen M.L. Malak
ResearchOpen Access25 May 2025
Scientific Reports

Volume: 15, P: 1-11
A resource of induced pluripotent stem cell (iPSC) lines including clinical, genomic, and cellular data from genetically isolated families with mood and psychotic disorders

Sevilla D. Detera-Wadleigh
Layla Kassem
Francis J. McMahon
ResearchOpen Access16 Dec 2023
Translational Psychiatry

Volume: 13, P: 1-10
LINC01638 sustains human mesenchymal stem cell self-renewal and competency for osteogenic cell fate

Jonathan A. R. Gordon
Coralee E. Tye
Jane B. Lian
ResearchOpen Access20 Nov 2023
Scientific Reports

Volume: 13, P: 1-14
LncMIR181A1HG is a novel chromatin-bound epigenetic suppressor of early stage osteogenic lineage commitment

Coralee E. Tye
Prachi N. Ghule
Gary S. Stein
ResearchOpen Access11 May 2022
Scientific Reports

Volume: 12, P: 1-16
Generation of a nodal line and Weyl points by magnetization reorientation in Co₃Sn₂S₂

F. Schilberth
M.-C. Jiang
S. Bordács
ResearchOpen Access01 Jul 2025
npj Quantum Materials

Volume: 10, P: 1-7
HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders

Sigrid Le Clerc
Laura Lombardi
Ryad Tamouza
ResearchOpen Access08 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Anna H. Ou
Sara B. Rosenthal
John R. Kelsoe
ResearchOpen Access23 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-9
Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
Amendments and CorrectionsOpen Access08 Jan 2025
Nature

Volume: 637, P: E26
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Azmeraw T. Amare
Anbupalam Thalamuthu
Bernhard T. Baune
ResearchOpen Access11 Jul 2023
Molecular Psychiatry

Volume: 28, P: 5251-5261
Erratum: Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder

D T Chen
X Jiang
F J McMahon
Amendments and Corrections24 Jan 2013
Molecular Psychiatry

Volume: 18, P: 264-266
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder

T G Schulze
S D Detera-Wadleigh
F J McMahon
Research16 Dec 2008
Molecular Psychiatry

Volume: 14, P: 487-491
Germline genomic variants associated with childhood acute lymphoblastic leukemia

Mary Relling and colleagues report results of a genome-wide association study of childhood acute lymphoblastic leukemia (ALL) and its subtypes, identifying a specific association between common variants in ARID5B and B-hyperdiploid ALL.

Lisa R Treviño
Wenjian Yang
Mary V Relling
Research16 Aug 2009
Nature Genetics

Volume: 41, P: 1001-1005
Role of saltmarsh systems in estuarine trapping of microplastics

Chiedozie C. Ogbuagu
Hachem Kassem
Andrew B. Cundy
ResearchOpen Access15 Sept 2022
Scientific Reports

Volume: 12, P: 1-14
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Future intensification of extreme Aleutian low events and their climate impacts

K. Giamalaki
C. Beaulieu
D. Faranda
ResearchOpen Access15 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines

M Acharya
A L Edkins
W Cushley
Research16 Jul 2009
Leukemia

Volume: 23, P: 1807-1817
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder

Marisol Herrera-Rivero
Karina Gutiérrez-Fragoso
Bernhard T. Baune
ResearchOpen Access03 Apr 2024
Translational Psychiatry

Volume: 14, P: 1-10
microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells

D Hamam
D Ali
N M Alajez
ResearchOpen Access30 Oct 2014
Cell Death & Disease

Volume: 5, P: e1499
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder

D T Chen
X Jiang
F J McMahon
Research20 Dec 2011
Molecular Psychiatry

Volume: 18, P: 195-205
A multiphasic characterization of the impact of the herbicide acetochlor on freshwater bacterial communities

Meghan E Foley
Von Sigler
Cyndee L Gruden
Research08 Nov 2007
The ISME Journal

Volume: 2, P: 56-66
Family-based association of FKBP5 in bipolar disorder

V L Willour
H Chen
J B Potash
Research08 Jan 2008
Molecular Psychiatry

Volume: 14, P: 261-268
A genome-wide association study of attempted suicide

V L Willour
F Seifuddin
J B Potash
Research22 Mar 2011
Molecular Psychiatry

Volume: 17, P: 433-444
Whole-genome association study of bipolar disorder

P Sklar
J W Smoller
S M Purcell
Research04 Mar 2008
Molecular Psychiatry

Volume: 13, P: 558-569
Genome-wide association study of bipolar disorder in European American and African American individuals

E N Smith
C S Bloss
J R Kelsoe
Research02 Jun 2009
Molecular Psychiatry

Volume: 14, P: 755-763

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