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Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

Single photon emitters (SPEs) in 2D semiconductors can be deterministically positioned using localized strain induced by underlying nanostructures. Here, the authors show SPE coupling in WSe₂ to GaP dielectric nanoantennas, substantially increasing quantum efficiency and photoluminescence brightness.

Sekar Kathiresan et al. report genome-wide association studies for polygenic dyslipidemia. From a meta-analysis of seven genome-wide association studies and follow-up in five replication studies, they identify 11 new genetic associations for LDL cholesterol, HDL cholesterol and triglycerides.

Genetic and environmental factors impact on lung function, important in the diagnosis of pulmonary diseases. Here the authors use imputation of genotypes to the 1000 Genomes Project reference panel to identify novel, low frequency variants associated with lung function.

Improved biomarker-based tools for diagnosis and risk prediction of venous thromboembolism (VTE) are needed. Here, the authors show that Complement Factor H Related 5 protein, a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker in 5 independent cohorts.

Martin Tobin and colleagues present genome-wide association studies for pulmonary function as part of the SpiroMeta consortium.

Spin-orbit interaction, and the associated phenomena, is commonly observed in crystalline structure pumped with circularly polarised beam. Here, the authors showed that this is not the case, and used nonlinear thin film to produce vortex beams of second-harmonic light.

A genome-wide association study for lung cancer finds that genetic sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute susceptibility. Interestingly, this susceptibility is not related to smoking status or frequency, and seems to come from a change in an amino acid in the receptor itself.

Simultaneous spin and orbital angular momentum conservation enables control over the divergence and polarization of EUV vortex beams, paving the way to ultrafast studies of chiral systems using high-harmonic beams with designer spin and orbital angular momentum.

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.

Exploiting both pulsed resonant excitation and a large Purcell enhancement, a single quantum dot coupled to a photonic crystal nanostructure can deterministically produce highly indistinguishable single photons for on-chip quantum optical applications.

Optical computing has the potential to be faster and more energy-efficient than conventional digital-electronic computing for certain applications. This Perspective article surveys the differences between optics and electronics that could be exploited, and explores the physics and engineering challenges in realizing useful optical computers.

Most efficient terahertz detection schemes rely on complex free space optics and require high-power lasers. Here, the authors report an integrated plasmonic terahertz detector on a silicon photonics platform, with 2.5 THz bandwidth and a 65 dB dynamical range operating at an optical power of only 63 nW.

A laser–plasma experiment has recreated shock waves in collisionless, weakly magnetized conditions and evidenced electron acceleration to relativistic energies, offering unprecedented insight into a long-standing problem in astrophysics.

Rosalind Eeles and colleagues report meta-analysis of genome-wide association studies for prostate cancer and genotyping on the custom iCOGS array in 25,074 cases and 24,272 controls from 32 studies available in the PRACTICAL Consortium. They identify 23 new prostate cancer susceptibility loci, 20 of which are associated with both aggressive and non-aggressive disease.

Arne Pfeufer and colleagues report a genome-wide association study of the electrocardiographic measurement of PR interval in seven population-based cohorts in the CHARGE consortium. They identify nine loci associated with PR interval and highlight candidate genes with a role in ion channels and cardiac development.

Laser beams travelling side-by-side through a medium usually only interact if they’re within a beam-diameter apart. An observation of the attraction and coalescence of high-power beams separated by several beam diameters in a plasma has implications for the development of laser-driven fusion.

Mercury is emitted by anthropogenic activities and accumulates in the Arctic. This Review presents a mercury budget for the Arctic, describing fluxes and cycling.

Single indistinguishable photon sources with high flux rates and purity are needed in quantum communications. Here, Gschreyet al. use three-dimensional electron-beam lithography to pattern deterministic quantum-dot microlenses and demonstrate enhanced photon-extraction efficiency and photon indistinguishability.

Here, the analysis of 'HapMap 3' is reported — a public data set of genomic variants in human populations. The resource integrates common and rare single nucleotide polymorphisms (SNPs) and copy number polymorphisms (CNPs) from 11 global populations, providing insights into population-specific differences among variants. It also demonstrates the feasibility of imputing newly discovered rare SNPs and CNPs.

Signal processors based on programmable photonic circuits will enable many future applications employing a common hardware platform. The authors present the architecture and two approaches to management automation to enable self-configuration and optimization of such photonic integrated circuits.

Kidney stones form in the presence of overabundance of crystal-forming substances such as Ca²⁺ and oxalate. Here, the authors report genome-wide association analyses for kidney stone disease, report seven previously unknown loci and find that some of these loci also associate with Ca²⁺ concentration and excretion.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Richard Houlston, Maria Teresa Landi and colleagues report the identification of large-effect associations for squamous lung cancer with rare variants in BRCA2 and CHEK2.

A phase modulator that is only 29 µm long and operates at 65 GHz is demonstrated using plasmonics and the Pockels effect in a nonlinear polymer. The device operates across a 120-nm-wide wavelength range centred on 1,550 nm and at temperatures up to 85 °C.

Caroline Fox and colleagues report results of a genome-wide association study to identify common variants associated with indices of renal function. They show that variants at UMOD, a gene previously implicated in rare monogenic forms of kidney disease, are associated with risk of chronic kidney disease in the general population.

Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.

Florent Soubrier and colleagues report a genome-wide association study of pulmonary arterial hypertension. They identify a susceptibility locus near CBLN2 associated with a twofold elevated risk of developing this life-threatening disease.

Martin Tobin and colleagues report a meta-analysis of 23 genome-wide association studies for pulmonary function. They identify 16 loci newly associated with variation in two cross-sectional measures of lung function, used to define airway obstruction and to grade the severity of obstruction.

Here, the authors demonstrate a chip-scale device that realizes a comprehensive set of resonant second order nonlinear processes including optical parametric oscillation with a threshold power of 70 microwatts.

Genetic variance can influence breast cancer prognosis. Here, the authors conduct a meta-analysis to explore genetic variance linked to breast cancer in young women, identifying a prognostic association with germline variation of ADAMTSL1.

Trees come in all shapes and size, but what drives this incredible variation in tree form remains poorly understood. Using a global dataset, the authors show that a combination of climate, competition, disturbance and evolutionary history shape the crown architecture of the world’s trees and thereby constrain the 3D structure of woody ecosystems.

Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, several of which show stronger effects in women than in men.

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

The world’s first integration of quantum key distribution and high-speed classical communications over field-deployed multi-core fiber.

Graphene-integrated photonics is a platform for wafer-scale manufacturing of modulators, detectors and switches for next-generation datacom and telecom systems. This Review describes how these functions can be achieved with graphene layers placed on top of optical waveguides, acting as passive light guides, thus simplifying the current technology. In addition, a roadmap of the technological requirements for the datacom and telecom markets is presented.

Wei Zheng and colleagues report genome-wide analyses in east Asians and identify three new loci associated with colorectal cancer risk.