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CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

Goel and colleagues show that CDK4/6 inhibition induces global chromatin changes mediated by AP-1 factors, which mediate key biological and clinical effects in breast cancer.

April C. Watt
Paloma Cejas
Shom Goel
Research09 Nov 2020
Nature Cancer

Volume: 2, P: 34-48
Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping

Sylvan C. Baca
Ji-Heui Seo
Matthew L. Freedman
Amendments and CorrectionsOpen Access04 Dec 2023
Nature Medicine

Volume: 30, P: 907
Liquid biopsy epigenomic profiling for cancer subtyping

In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug targets and resistance genes.

Sylvan C. Baca
Ji-Heui Seo
Matthew L. Freedman
ResearchOpen Access21 Oct 2023
Nature Medicine

Volume: 29, P: 2737-2741
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

Innate lymphoid cells (ILCs) have been found in gut and lungs. Weninger and colleagues identify IL-13-producing ILCs in the skin, where they interact with mast cells and regulate allergic responses.

Ben Roediger
Ryan Kyle
Wolfgang Weninger
Research21 Apr 2013
Nature Immunology

Volume: 14, P: 564-573
Chromatin signature of embryonic pluripotency is established during genome activation

To study the changes in chromatin structure that accompany zygotic genome activation and pluripotency during the maternal–zygotic transition (MZT), the genomic locations of histone H3 modifications and RNA polymerase II have been mapped during this transition in zebrafish embryos. H3 lysine 27 trimethylation and H3 lysine 4 trimethylation are only detected after MZT; evidence is provided that the bivalent chromatin domains found in cultured embryonic stem cells also exist in embryos.

Nadine L. Vastenhouw
Yong Zhang
Alexander F. Schier
Research24 Mar 2010
Nature

Volume: 464, P: 922-926
A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia

S Le Clerc
L Taing
M Leboyer
ResearchOpen Access28 Jul 2015
Translational Psychiatry

Volume: 5, P: e608
Temporal lobe activation during episodic memory encoding following traumatic brain injury

Abbie S. Taing
Matthew E. Mundy
Gershon Spitz
ResearchOpen Access22 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile

Krinio Giannikou
Zachary Zhu
David J. Kwiatkowski
Research13 Oct 2020
Modern Pathology

Volume: 34, P: 264-279
Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight

L López-Ferreras
J E Richard
K P Skibicka
ResearchOpen Access12 Sept 2017
Molecular Psychiatry

Volume: 23, P: 1157-1168

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