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Advanced filters: Author: L. Colombi Ciacchi Clear advanced filters

  • Ayala Mariscal et al have identified and characterized the interface of pathogenic Huntingtin and the molecular chaperone DNAJB1. Histidine-244 of the C-terminal domain of DNAJB1 is a key residues for binding to the poly-proline region of HTT. This binding site is specific for the interaction with Huntingtin.

    • S. M. Ayala Mariscal
    • M. L. Pigazzini
    • J. Kirstein
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-25