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Little is known on how mitonuclear interactions influence genomic divergence among hybrid and parental lineages. A study of hybridizing wood warbler species complex finds a nuclear gene block with mitochondrial functions coevolves with mitochondrial genome, driven by climate-associated divergent selection underlying hybrid-parental population divergence.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

What is the state of trust in scientists around the world? To answer this question, the authors surveyed 71,922 respondents in 68 countries and found that trust in scientists is moderately high.

Reference-free integrative analysis of spatial transcriptomics data is achieved with archetype analysis.

A near-miss ecological disaster still left a sinister aftermath for these giant lizards.

The Deepwater Horizon disaster was the largest accidental discharge of oil into the environment, and was intensely studied during and after the event. In this Review, the subsequent advances made in oil chemistry, dispersant application, and microbiology are discussed.

Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

Deoxygenation in the North Pacific immediately after the Cordilleran ice sheet retreat was shown to be linked with volcanism, suggesting that coupling between atmosphere, ocean, cryosphere and solid-Earth systems can drive biogeochemical change.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

A targeted protein stabilization platform termed deubiquitinase-targeting chimera (DUBTAC) was developed based on heterobifunctional small molecules consisting of a deubiquitinase OTUB1 recruiter linked to a protein-targeting ligand.

High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.

Seder and colleagues use a self-assembling nanoparticle vaccine and adjuvant to expand stem-like CD8⁺ T cells and trigger potent antitumor responses.

Prostate epithelia contain basal, luminal and neuroendocrine cells. Here the authors show that overexpression of the Notch intracellular domain in the mouse prostate promotes proliferation and suppresses anoikis of prostate luminal epithelial cells.

Cancer vaccines that self-assemble into uniform nanoparticles improve tumor clearance.

Analyses of the proportions of individuals who have completed key levels of schooling across all low- and middle-income countries from 2000 to 2017 reveal inequalities across countries as well as within populations.

Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2 variants Delta and Omicron BA.1.

Rapid extracellular antigen profiling of a cohort of 194 individuals infected with SARS-CoV-2 uncovers diverse autoantibody responses that affect COVID-19 disease severity, progression and clinical and immunological characteristics.

A longitudinal analysis of humoral immune responses in patients with COVID-19 with varying disease severities reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion.

Most carbon capture technologies rely on corrosive amine solutions, or high surface area materials. Here, the authors fabricate polymer microcapsules with liquid carbonate cores and permeable silicone shells combining the capacity of liquid sorbents with the surface area and low volatility of solid materials.

Microscopy has undoubtedly advanced biomedical research, but novel hypotheses are often lost to a lack of analytical tools. Here authors propose iCLOTS, a freely-available software that allows researchers to apply image processing and artificial intelligence algorithms to their own data.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

A longitudinal analysis of immune responses in patients with moderate or severe COVID-19 identifies a maladapted immune response profile linked to severe disease.

Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.

There have been five independent transitions from egg laying to live birth in the phrynosomatid lizards. Here, Domínguez-Guerrero et al. identify parallel changes in physiology, life history and behaviour that characterize these transitions to live birth.

This Perspective examines the challenges to equitable participation of migrants and immigrants in genetics research and proposes inclusive, community-driven approaches to advance scientific discovery and overcome health disparities.

Trp-tRNA synthetase (TrpRS) has a well-understood role in translation by facilitating aminoacylation of Trp-tRNAs. The discovery of a nuclear signaling role for TrpRS as a bridging protein for DNA-PK and PARP-1, resulting in p53 activation, explains a previously curious link between interferon-γ signaling and concomitant TrpRS overexpression.

Here, in a follow-up of a clinical study, the authors show that protein pacing and intermittent fasting improves gut symptomatology and microbial diversity, as well as reduces visceral fat compared to a heart-healthy, calorie-restricted diet matched for overall energy intake and expenditure in free-living humans.

Here, the authors investigate the aboveground carbon sink efficiency of Andean forests. The study shows the high potential of these forests to serve as future carbon refuges, and urges to reduce deforestation and increase restoration.

Male patients with COVID-19 have higher plasma levels of innate immune cytokines and chemokines such as IL-8, IL-18 and CCL5 and more non-classical monocytes than female patients, whereas female patients mount robust T cell activation maintained even in older age.

Disease signatures in high-dimensional biomedical data are detected with a visualization algorithm.

Early-warning changes in precancerous epithelial cells can now be spotted in situ.