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Showing 51–100 of 167 results

Advanced filters: Author: L. Pfeifer Clear advanced filters

Ebola virus antibody decay–stimulation in a high proportion of survivors

In many survivors of Ebola virus infection, antibody responses show long-term patterns of decline followed by restimulation, possibly owing to recrudescence of persisting virus.

Charlene Adaken
Janet T. Scott
Georgios Pollakis
Research27 Jan 2021
Nature

Volume: 590, P: 468-472
Mammoth ivory was the most suitable osseous raw material for the production of Late Pleistocene big game projectile points

Sebastian J. Pfeifer
Wolfram L. Hartramph
Frank A. Müller
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis

Martin C Herzig
David T Winkler
Mathias Jucker
Research15 Aug 2004
Nature Neuroscience

Volume: 7, P: 954-960
Enhancing astaxanthin biosynthesis and pathway expansion towards glycosylated C40 carotenoids by Corynebacterium glutamicum

Vanessa L. Göttl
Florian Meyer
Nadja A. Henke
ResearchOpen Access06 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 282-291
Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS

This study demonstrates that the cytosolic helicases RIG-I and MDA5 act to negatively regulate the expansion of the encephalitogenic T_H1 and T_H17 T cells via a mechanism that induces type I interferon production specifically in dendritic cells. Activating this pathway leads to decreased pathology in response to CNS autoimmunity.

Angela Dann
Hendrik Poeck
Marco Prinz
Research04 Dec 2011
Nature Neuroscience

Volume: 15, P: 98-106
Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis

Grieger, Takele, Vesco, et al. perform a systematic review and meta-analysis of gestational weight gain interventions. Findings indicate lifestyle interventions that reduce excessive gestational weight gain provide greater benefits for women with a normal BMI and higher HDL cholesterol levels at the initiation of interventions.

Jessica A. Grieger
Wubet Worku Takele
Siew Lim
ResearchOpen Access24 Oct 2025
Communications Medicine

Volume: 5, P: 1-13
δ-(L-α-Aminoadipyl)-L-Cysteinyl-D-Valine Synthetase, the Multienzyme Integrating the Four Primary Reactions in β-Lactam Biosynthesis, as a Model Peptide Synthetase

Yair Aharonowitz
Jürgen Bergmeyer
Jinyou Zhang
Reviews01 Jul 1993
Bio/Technology

Volume: 11, P: 807-810
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1

Love and colleagues show that THEMIS enhances the TCR signaling response to low-affinity ligands by inhibiting the tyrosine-phosphatase activity of SHP-1.

Seeyoung Choi
Claude Warzecha
Paul E Love
Research27 Feb 2017
Nature Immunology

Volume: 18, P: 433-441
Maternal handling during pregnancy reduces DMBA-induced mammary tumorigenesis among female offspring

L Hilakivi-Clarke
Research01 Jul 1997
British Journal of Cancer

Volume: 76, P: 150-155
Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

The autophagy proteins Beclin 1 and FIP200, but not other essential autophagy components, such as ATG5, ATG16L1 or ATG7, regulate quiescence of tissue-resident macrophages, thereby modulating immune activation and resistance to Listeria monocytogenes infection.

Ya-Ting Wang
Konstantin Zaitsev
Herbert W. Virgin
Research20 Jan 2020
Nature Microbiology

Volume: 5, P: 272-281
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

A systematic review of evidence, across the key pillars of prevention, diagnosis, treatment and prognosis, outlines milestones that need to be met to enable the broad clinical implementation of precision medicine in diabetes care.

Deirdre K. Tobias
Jordi Merino
Paul W. Franks
Reviews05 Oct 2023
Nature Medicine

Volume: 29, P: 2438-2457
Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72

M Reinbold
J-L Luo
M Hollstein
Research12 Nov 2007
Oncogene

Volume: 27, P: 2788-2794
Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer

MO Hiltunen
J Koistinaho
J Jänne
Research01 Nov 1997
British Journal of Cancer

Volume: 76, P: 1124-1130
Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
Quantifying global soil carbon losses in response to warming

A compilation of global soil carbon data from field experiments provides empirical evidence that warming-induced net losses of soil carbon could accelerate climate change.

T. W. Crowther
K. E. O. Todd-Brown
M. A. Bradford
Research30 Nov 2016
Nature

Volume: 540, P: 104-108
The LIM homeobox gene Lhx9 is essential for mouse gonad formation

Ohad S. Birk
Delane E. Casiano
Heiner Westphal
Research24 Feb 2000
Nature

Volume: 403, P: 909-913
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707
Technology Insight: therapeutic RNA interference—how far from the neurology clinic?

Last year's Nobel Prize in Physiology or Medicine was won by Andrew Fire and Craig Mello for their discovery of RNA interference, an evolutionarily conserved cellular pathway that regulates endogenous gene expression. In this Review, Gonzalez and Paulson discuss how RNA interference is being exploited experimentally to suppress the expression of dominantly acting genes that cause incurable neurodegenerative disorders, and highlight the questions that need to be answered before human clinical trials of this technology can commence.

Pedro Gonzalez-Alegre
Henry L Paulson
Reviews01 Jul 2007
Nature Clinical Practice Neurology

Volume: 3, P: 394-404
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking

Epigenetic clocks are widely used aging biomarkers, but their utility is limited by technical noise. The authors report a method for producing high-reliability clocks for applications such as longitudinal studies and intervention trials.

Albert T. Higgins-Chen
Kyra L. Thrush
Morgan E. Levine
Research15 Jul 2022
Nature Aging

Volume: 2, P: 644-661
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κB pathway.

Irene Santos-Barriopedro
Laia Bosch-Presegué
Alejandro Vaquero
ResearchOpen Access09 Jan 2018
Nature Communications

Volume: 9, P: 1-15
Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response

Victoria L. Fell
Elizabeth A. Walden
Caroline Schild-Poulter
ResearchOpen Access16 Nov 2016
Scientific Reports

Volume: 6, P: 1-17
RASSF1A interacts with and activates the mitotic kinase Aurora-A

L Liu
C Guo
G P Pfeifer
Research21 Jul 2008
Oncogene

Volume: 27, P: 6175-6186
Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

RNA antisense oligonucleotide therapy to restore normal splicing of a ciliopathy gene shows promising safety and efficacy results in a clinical trial to treat a form of childhood blindness.

Artur V. Cideciyan
Samuel G. Jacobson
Stephen R. Russell
Research17 Dec 2018
Nature Medicine

Volume: 25, P: 225-228
Combined RAF1 protein expression and p53 mutational status provides a strong predictor of cellular radiosensitivity

H M Warenius
M Jones
P Rudland
ResearchOpen Access19 Sept 2000
British Journal of Cancer

Volume: 83, P: 1084-1095
The British Association

C. WILLIAM SIEMENS
News24 Aug 1882
Nature

Volume: 26, P: 390-414
Spontaneous movement of ions through calcite at standard temperature and pressure

S. L. S. Stipp
J. Konnerup-Madsen
H. J. Mathieu
Research26 Nov 1998
Nature

Volume: 396, P: 356-359
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Svenja Sydor
Paul Manka
Lars P. Bechmann
ResearchOpen Access14 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
‘My appetite and mind would go’: Inuit perceptions of (im)mobility and wellbeing loss under climate change across Inuit Nunangat in the Canadian Arctic

Sonja Ayeb-Karlsson
Anna Hoad
Mei L. Trueba
ReviewsOpen Access16 Feb 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-20
The AIMe registry for artificial intelligence in biomedical research

We present the AIMe registry, a community-driven reporting platform for AI in biomedicine. It aims to enhance the accessibility, reproducibility and usability of biomedical AI models, and allows future revisions by the community.

Julian Matschinske
Nicolas Alcaraz
David B. Blumenthal
Comments & Opinion25 Aug 2021
Nature Methods

Volume: 18, P: 1128-1131
Archaeal genetics — the third way

Thorsten Allers
Moshe Mevarech
Reviews01 Jan 2005
Nature Reviews Genetics

Volume: 6, P: 58-73
Active DNA demethylation: many roads lead to Rome

Despite its role in long-term gene silencing, DNA methylation is more dynamic than originally thought. Active DNA demethylation occurs during specific stages of development and there is growing evidence to suggest that multiple mechanisms for active DNA demethylation exist.

Susan C. Wu
Yi Zhang
Reviews04 Aug 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 607-620
Germplasm dynamics: the role of ecotypic diversity in shaping the patterns of genetic variation in Lolium perenne

T. Blackmore
D. Thorogood
M. Hegarty
ResearchOpen Access03 Mar 2016
Scientific Reports

Volume: 6, P: 1-11
Genomic signals of local adaptation across climatically heterogenous habitats in an invasive tropical fruit fly (Bactrocera tryoni)

Elahe Parvizi
Amy L. Vaughan
Angela McGaughran
ResearchOpen Access30 Oct 2023
Heredity

Volume: 132, P: 18-29
JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia

Christoph Klein and colleagues identify homozygous mutations in the JAGN1 gene in families and individuals with severe congenital neutropenia. They show that JAGN1 is necessary for the differentiation and survival of neutrophil granulocytes.

Kaan Boztug
Päivi M Järvinen
Christoph Klein
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 1021-1027
Arabinogalactan-proteins of Zostera marina L. contain unique glycan structures and provide insight into adaption processes to saline environments

Lukas Pfeifer
Thomas Shafee
Birgit Classen
ResearchOpen Access19 May 2020
Scientific Reports

Volume: 10, P: 1-14
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

James R Eshleman
Graham Casey
Sanford D Markowitz
Research14 Aug 1998
Oncogene

Volume: 17, P: 719-725
A role for chromosomal instability in the development of and selection for radioresistant cell variants

C L Limoli
J J Corcoran
J L Schwartz
ResearchOpen Access13 Feb 2001
British Journal of Cancer

Volume: 84, P: 489-492
Cessation of Neoangiogenesis in Alzheimer's Disease Follows Amyloid-beta Immunization

Kaan E. Biron
Dara L. Dickstein
Wilfred A. Jefferies
ResearchOpen Access28 Feb 2013
Scientific Reports

Volume: 3, P: 1-7
The relative contribution of natural landscapes and human-mediated factors on the connectivity of a noxious invasive weed

Diego F. Alvarado-Serrano
Megan L. Van Etten
Regina S. Baucom
Research02 Jul 2018
Heredity

Volume: 122, P: 29-40
RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice

Antje M. Richter
Michelle L. Woods
Reinhard H. Dammann
ResearchOpen Access11 Feb 2020
Oncogene

Volume: 39, P: 3114-3127
Associations among telomerase activity, p53 protein overexpression, and genetic instability in lung cancer

X Wu
B Kemp
M R Spitz
ResearchOpen Access09 Apr 1999
British Journal of Cancer

Volume: 80, P: 453-457
The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation

T. Druck
J. Podolski
K. Huebner
Research01 Oct 2001
Journal of Human Genetics

Volume: 46, P: 583-589
Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts

Amy L. Gillespie
Emma M. Walker
James H. MacCabe
ResearchOpen Access27 Sept 2024
Translational Psychiatry

Volume: 14, P: 1-11
Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis

Ahmad, Lim, Morieri, Tam et al perform a systematic review and meta-analysis of biomarkers, genetic markers, and risk scores for prediction of cardiovascular outcomes in Type 2 diabetes. A few prognostic markers are identified that provide incremental predictive utility beyond established cardiovascular risk factors.

Abrar Ahmad
Lee-Ling Lim
Nestoras Mathioudakis
ResearchOpen Access22 Jan 2024
Communications Medicine

Volume: 4, P: 1-28
Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state

A Avignon
C Bœgner
L Monnier
Research26 May 1999
International Journal of Obesity

Volume: 23, P: 512-517
Digital gait biomarkers in Parkinson’s disease: susceptibility/risk, progression, response to exercise, and prognosis

Martina Mancini
Mitra Afshari
Daniel M. Corcos
ReviewsOpen Access21 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-18
TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling

Inactivation of three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling, revealing a functional redundancy of Tet genes and showing balanced and dynamic DNA methylation and demethylation is crucial to regulate key signalling pathways in early body plan formation.

Hai-Qiang Dai
Bang-An Wang
Guo-Liang Xu
Research19 Oct 2016
Nature

Volume: 538, P: 528-532
Tissue-specific mutation accumulation in human adult stem cells during life

Stem cells of the liver, colon and small intestine gradually accumulate mutations throughout life at a similar rate even though cancer incidence varies greatly among these tissues.

Francis Blokzijl
Joep de Ligt
Ruben van Boxtel
Research03 Oct 2016
Nature

Volume: 538, P: 260-264
Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons

Brett A. Eyford
Maciej J. Lazarczyk
Wilfred A. Jefferies
ResearchOpen Access11 Aug 2023
Scientific Reports

Volume: 13, P: 1-10

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