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Showing 1–3 of 3 results
Advanced filters: Author: Lachlan Clydesdale Clear advanced filters

  • The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by these ligands, including distinct kinetics of G protein activation.

    • Giuseppe Deganutti
    • Yi-Lynn Liang
    • Denise Wootten
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • The structure of GLP-1R and its G protein in complex with the small molecule TT-OAD2 sheds light on how the TT-OAD2 agonist can activate the receptor and provides insights into the development of therapeutic agents for metabolic disorders.

    • Peishen Zhao
    • Yi-Lynn Liang
    • Denise Wootten
    Research
    Nature
    Volume: 577, P: 432-436