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Showing 1–6 of 6 results
Advanced filters: Author: Lachlan W. Richardson Clear advanced filters

  • Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

    • Abel Brodeur
    • Derek Mikola
    • Yaolang Zhong
    Research
    Nature
    Volume: 652, P: 151-156

  • Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis.

    • Andre L. Samson
    • Ying Zhang
    • James M. Murphy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion.

    • Niall D. Geoghegan
    • Cindy Evelyn
    • Kelly L. Rogers
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and identify specific functional differences.

    • Xiangyi S. Wang
    • Thomas R. Cotton
    • Bernhard C. Lechtenberg
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Multiangle projection imaging accelerates volumetric imaging by up to two orders of magnitude and is readily implemented on diverse microscopes, including spinning disk confocal and light-sheet microscopes.

    • Bo-Jui Chang
    • James D. Manton
    • Reto Fiolka
    Research
    Nature Methods
    Volume: 18, P: 829-834

  • This study demonstrates that co-clustering of the EphB6 receptor tyrosine pseudokinase with its ephrinB1 ligand on neighboring cells promotes formation of intercellular tubules. This stabilizes cell-cell adhesion and reduces cancer cell invasion.

    • Lung-Yu Liang
    • Niall D. Geoghegan
    • Isabelle S. Lucet
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-13