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Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials

Robert Montal
Carmen Andreu-Oller
Josep M. Llovet
ResearchOpen Access09 Jul 2019
British Journal of Cancer

Volume: 121, P: 340-343
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Batlle and colleagues develop an organoid platform for functional antibody screening and identify a therapeutic bispecific antibody that binds EGFR and LGR5 and that shows efficacy across epithelial tumor patient-derived xenograft models in vivo.

Bram Herpers
Berina Eppink
Mark Throsby
Research25 Apr 2022
Nature Cancer

Volume: 3, P: 418-436
Role of Kupffer cells in the progression of CRC liver metastases after the first stage of ALPPS

Rocio García-Pérez
Joana Ferrer Fábrega
José Fuster Obregón
ResearchOpen Access24 May 2018
Scientific Reports

Volume: 8, P: 1-8
Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma is an aggressive cancer of the bile duct with few treatment options and a below 10% five-year survival rate. Here Sia et al. show a novel FGFR2–PPHLN1 fusion and ARAFmutations that may represent future potential therapeutic targets.

Daniela Sia
Bojan Losic
Josep M. Llovet
Research22 Jan 2015
Nature Communications

Volume: 6, P: 1-11

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