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Showing 1–2 of 2 results
Advanced filters: Author: Lam-Shing Chan Clear advanced filters

  • KRAS mutations are associated with an immunosuppressive microenvironment in patients with colorectal cancer (CRC). Here the authors show that knockout of SLC25A22, a mitochondrial glutamate carrier, reverts KRAS-mediated immunosuppression in preclinical CRC models, by suppressing CXCL1 production and impairing MDSC recruitment.

    • Qiming Zhou
    • Yao Peng
    • Chi Chun Wong
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic target in KRASmutant colorectal cancer.

    • Chi Chun Wong
    • Jian-Lin Wu
    • Jun Yu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15