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Showing 1–3 of 3 results
Advanced filters: Author: Lambert M G Van Golde Clear advanced filters

  • Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

    • Rebecca Sims
    • Sven J van der Lee
    • Gerard D Schellenberg
    Research
    Nature Genetics
    Volume: 49, P: 1373-1384

  • This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet and infections, and host-intrinsic factors, such as the activity of microglial cells and other immune, vascular and neuronal cell populations, on disease development. They also highlight emerging drugs that target this inflammatory component for therapy of Alzheimer disease.

    • Michael T. Heneka
    • Wiesje M. van der Flier
    • Sean-Patrick Riechers
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 321-352