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Showing 1–7 of 7 results
Advanced filters: Author: Lamine Koivogui Clear advanced filters

  • Patients who have recovered from Ebola virus can have ongoing health problems. Here, the authors show that 35 Guinean survivors of the last West African Ebola epidemic have a chronic disease with high inflammatory cytokine expression and other markers of immune activation as well as evidence of intestinal tissue damage nearly two years after their release from hospital.

    • Aurélie Wiedemann
    • Emile Foucat
    • Abdoulaye Touré
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • An analysis of 85 Ebola virus sequences collected in Guinea from July to November 2014 provides insight into the evolution of the Ebola virus responsible for the epidemic in West Africa; the results show sustained transmission of three co-circulating lineages, each defined by multiple mutations.

    • Etienne Simon-Loriere
    • Ousmane Faye
    • Amadou A. Sall
    ResearchOpen Access
    Nature
    Volume: 524, P: 102-104

  • In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

    • Aurélie Wiedemann
    • Edouard Lhomme
    • Huanying Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • A nanopore DNA sequencer is used for real-time genomic surveillance of the Ebola virus epidemic in the field in Guinea; the authors demonstrate that it is possible to pack a genomic surveillance laboratory in a suitcase and transport it to the field for on-site virus sequencing, generating results within 24 hours of sample collection.

    • Joshua Quick
    • Nicholas J. Loman
    • Miles W. Carroll
    Research
    Nature
    Volume: 530, P: 228-232

  • Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8+ T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.

    • Paula Ruibal
    • Lisa Oestereich
    • César Muñoz-Fontela
    Research
    Nature
    Volume: 533, P: 100-104