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Showing 1–3 of 3 results
Advanced filters: Author: Lance D. Hentges Clear advanced filters

  • The authors demonstrate efficient and direct correction of the DNA mutation causing Haemoglobin E β-thalassaemia with CRISPR Cas9 base editors. The work includes profiling of off-target effects using deep neural networks.

    • Mohsin Badat
    • Ayesha Ejaz
    • James O. J. Davies
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7

  • Micro Capture-C allows physical contacts to be determined at base-pair resolution, revealing that transcription factors have an important role in the maintenance of the contacts between enhancers and promoters.

    • Peng Hua
    • Mohsin Badat
    • James O. J. Davies
    Research
    Nature
    Volume: 595, P: 125-129

  • Martin Sergeant et al. develop a web-based tool called Multi Locus View that allows researchers to interact with genomics datasets at multiple scales. Users can browse, annotate, combine or analyse raw data on this interface. The user datasets generated in this tool can also be made public. This tool is expected to increase public access to the entirety of genomic data.

    • Martin J. Sergeant
    • Jim R. Hughes
    • Stephen Taylor
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-7