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Initiation of transcription-coupled repair characterized at single-molecule resolution

The early stages of transcription-coupled DNA repair are observed at single-molecule resolution; the Escherichia coli DNA translocase molecule Mfd is shown to promote RNA polymerase dissociation by catalysing two irreversible, ATP-dependent transitions.

Kévin Howan
Abigail J. Smith
Terence R. Strick
Research09 Sept 2012
Nature

Volume: 490, P: 431-434
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

Iliev et al. report that increased Candida albicans accumulation in the mycobiota of patients with severe COVID-19 might be a contributing factor to the immunopathology of severe COVID-19 and have long-lasting effects on the hematopoietic stem cell compartment.

Takato Kusakabe
Woan-Yu Lin
Iliyan D. Iliev
Research23 Oct 2023
Nature Immunology

Volume: 24, P: 1879-1889
Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections

Here, the authors isolate a SARS-CoV-2 mutant that has developed decreased sensitivity to Paxlovid and remdesivir from an immunocompromised patient, show that drug resistance can be overcome by simultaneous treatment with both drugs in vitro, and demonstrate that the drug resistant virus can efficiently transmit in the hamster model.

Mohammed Nooruzzaman
Katherine E. E. Johnson
Mirella Salvatore
ResearchOpen Access18 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Here, using clinical samples and autopsy tissues, the authors combine fast-colorimetric test (LAMP) for SARS-CoV-2 infection and large-scale shotgun metatranscriptomics for host, viral, and microbial profiling and provide a map of the viral genetic features of the New York City outbreak and associate specific host responses and gene expression perturbations with SARS-CoV-2 infection.

Daniel Butler
Christopher Mozsary
Christopher E. Mason
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-17
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection

Urinary tract infections (UTIs) are associated with changes in the gut microbiome. Here, the authors evaluate the relationship between the gut microbiome and development of UTI in kidney transplant patients and show that uropathogenic gut abundance might represent a risk factor for development of bacteriuria and UTI.

Matthew Magruder
Adam N. Sholi
John Richard Lee
ResearchOpen Access04 Dec 2019
Nature Communications

Volume: 10, P: 1-9
Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients

Emily M. Eichenberger
Rosemary Soave
Michael J. Satlin
Research01 Nov 2018
Bone Marrow Transplantation

Volume: 54, P: 1058-1066
Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract

Urinary tract infections are one of the most common infections in humans. Here, the authors use urinary cell-free DNA (cfDNA) to comprehensively monitor host and pathogen dynamics in bacterial and viral urinary tract infections, and show that it is a versatile analyte for monitoring urinary tract infections.

Philip Burnham
Darshana Dadhania
Iwijn De Vlaminck
ResearchOpen Access20 Jun 2018
Nature Communications

Volume: 9, P: 1-10
Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis

A comparison of the evolutionary history and geographical spread of the antimicrobial-resistant pathogen Staphylococcus capitis in neonatal intensive care units indicates that acquisition of antibiotic resistance and increased competitiveness have led to the success of the NRCS-A S. capitis clone.

Thierry Wirth
Marine Bergot
Cristina Prat Aymerich
Research27 Apr 2020
Nature Microbiology

Volume: 5, P: 735-745

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Initiation of transcription-coupled repair characterized at single-molecule resolution

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection

Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients

Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract

Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis

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