Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Lars L. P. Hanssen Clear advanced filters

  • Micro Capture-C allows physical contacts to be determined at base-pair resolution, revealing that transcription factors have an important role in the maintenance of the contacts between enhancers and promoters.

    • Peng Hua
    • Mohsin Badat
    • James O. J. Davies
    Research
    Nature
    Volume: 595, P: 125-129

  • Results from the DiViD Intervention, a phase 2 randomized, placebo-controlled trial, showed that antiviral treatment with pleconaril and ribavirin for 6 months resulted in higher endogenous insulin production in children and adolescents with new-onset type 1 diabetes.

    • Lars Krogvold
    • Ida Maria Mynarek
    • Knut Dahl-Jørgensen
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2902-2908

  • Douglas Higgs and colleagues functionally test the α-globin super-enhancer in mice by genetically deleting its constituent enhancers. They find that the individual regulatory elements seem to act independently and in an additive way with respect to hematological phenotype, gene expression, and chromatin structure and conformation.

    • Deborah Hay
    • Jim R Hughes
    • Douglas R Higgs
    Research
    Nature Genetics
    Volume: 48, P: 895-903

  • The coordination of interactions between multiple regulatory elements and genes within a chromatin domain remains poorly understood. Here, the authors use a method to detect multi-way chromatin interactions in a mouse model in which the α-globin domain is extended to include several additional genes, finding that the promoters do not form mutually exclusive interactions with the enhancers, but all interact simultaneously in a single complex.

    • A. Marieke Oudelaar
    • Caroline L. Harrold
    • Jim R. Hughes
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by acetylation.

    • Andrew J. King
    • Duantida Songdej
    • Christian Babbs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15