Multiple cytokines in the proinflammatory IL-1 family share the co-receptor IL-1R3. Dinarello and colleagues show that a fully humanized antibody to IL-1R3 can effectively control inflammation and disease mediated not only by IL-1 but also by IL-33 and IL-36.
- Jesper Falkesgaard Højen
- Marie Louise Vindvad Kristensen
- Charles A. Dinarello
