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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Kathy Sivils and colleagues report results of a large-scale association study of Sjögren's syndrome, a common autoimmune disease. They confirm strong associations with the HLA region and establish genome-wide significant associations at several non-HLA loci implicated in both innate and adaptive immunity.

Christopher J Lessard
He Li
Kathy L Sivils
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1284-1292
Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Fiona Allum
Xiaojian Shao
Elin Grundberg
Amendments and Corrections29 Jul 2015
Nature Communications

Volume: 6, P: 1
Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system

Despite extensive research, the etiopathogenesis of primary Sjögren's syndrome is not well understood. In this article, the hypothesis that activation of the type I interferon system contributes to the disease process is outlined and potential new therapeutic targets from this system for Sjögren's syndrome are discussed.

Gunnel Nordmark
Gunnar V Alm
Lars Rönnblom
Reviews01 May 2006
Nature Clinical Practice Rheumatology

Volume: 2, P: 262-269
Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

The genetic architecture underlying Sjögren’s syndrome is not fully understood. Here, the authors perform a genome-wide association study to identify 10 new genetic risk regions, implicating genes involved in immune and salivary gland function.

Bhuwan Khatri
Kandice L. Tessneer
Christopher J. Lessard
ResearchOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1-17
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Large-scale Mendelian randomization and colocalization analyses using gene expression and soluble protein data for 1,263 actionable druggable genes, which encode protein targets for approved drugs or drugs in clinical development, identify IFNAR2 and ACE2 as the most promising therapeutic targets for early management of COVID-19.

Liam Gaziano
Claudia Giambartolomei
Juan P. Casas
Research09 Apr 2021
Nature Medicine

Volume: 27, P: 668-676
Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Bhuwan Khatri
Kandice L. Tessneer
Christopher J. Lessard
Amendments and CorrectionsOpen Access03 Feb 2023
Nature Communications

Volume: 14, P: 1-3
Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Bhuwan Khatri
Kandice L. Tessneer
Christopher J. Lessard
Amendments and CorrectionsOpen Access31 Oct 2022
Nature Communications

Volume: 13, P: 1
Learning from similarities between vaccine responses and SLE

Baseline immune variation predicts immune responses during vaccination, and the gene signatures capturing such immune variation seem to correlate with systemic lupus erythematosus (SLE) disease activity. Will the definition of these gene sets enable the development of the much needed concept of personalized medicine in SLE?

Marie Wahren-Herlenius
Lars Rönnblom
News & Views17 Apr 2020
Nature Reviews Rheumatology

Volume: 16, P: 355-356
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements

Obesity and related metabolic complications represent an important health burden. Here the authors carry out a methylC-capture sequencing-based epigenome-wide association study to link circulating plasma lipid levels, CpG methylation and cardiometabolic risk across adipose and blood tissues.

Fiona Allum
Åsa K. Hedman
Elin Grundberg
ResearchOpen Access14 Mar 2019
Nature Communications

Volume: 10, P: 1-13
Cytokines as therapeutic targets in SLE

A number of cytokine pathways are important in the disease process of SLE, and several biological agents for SLE have been developed that target different cytokines or their receptors. This Review discusses the rationale for the use of anticytokine therapies in SLE, reviews the different agents tested to date, and presents future directions for therapy.

Lars Rönnblom
Keith B. Elkon
Reviews04 May 2010
Nature Reviews Rheumatology

Volume: 6, P: 339-347
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Currently, genome-wide methylation studies are limited to using targeted arrays or enrichment to assess large sample sizes. Here, Allum et al. demonstrate MethylC-Capture Sequencing, a cost-effective method for investigating genetic and epigenetic variation.

Fiona Allum
Xiaojian Shao
Elin Grundberg
ResearchOpen Access29 May 2015
Nature Communications

Volume: 6, P: 1-12
Transancestral mapping and genetic load in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.

Carl D. Langefeld
Hannah C. Ainsworth
Timothy J. Vyse
ResearchOpen Access17 Jul 2017
Nature Communications

Volume: 8, P: 1-18
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Timothy Vyse and colleagues report the results of a large-scale association study of systemic lupus erythematosus (SLE). They identify ten new susceptibility loci and implicate aberrant regulation of innate and adaptive immunity genes in disease pathogenesis.

James Bentham
David L Morris
Timothy J Vyse
Research26 Oct 2015
Nature Genetics

Volume: 47, P: 1457-1464
An epigenome-wide association study of total serum immunoglobulin E concentration

A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a population sample has revealed associations at 36 loci that harbour genes encoding proteins including eosinophil products and phospholipid inflammatory mediators.

Liming Liang
Saffron A. G. Willis-Owen
William O. C. M. Cookson
Research18 Feb 2015
Nature

Volume: 520, P: 670-674
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease among individuals of non-European ancestry.

David L Morris
Yujun Sheng
Timothy J Vyse
Research11 Jul 2016
Nature Genetics

Volume: 48, P: 940-946
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Robert Graham and colleagues report results of a large-scale replication study for systemic lupus erythematosus (SLE) in individuals of European ancestry. Their findings expand the number of confirmed SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.

Vesela Gateva
Johanna K Sandling
Robert R Graham
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1228-1233
Variants in BANK1 are associated with lupus nephritis of European ancestry

Karin Bolin
Juliana Imgenberg-Kreuz
Gunnel Nordmark
ResearchOpen Access14 Jun 2021
Genes & Immunity

Volume: 22, P: 194-202
A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts

Fabiana H. G. Farias
Johanna Dahlqvist
Kerstin Lindblad-Toh
ResearchOpen Access20 Nov 2018
European Journal of Human Genetics

Volume: 27, P: 432-441
Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison’s disease in Sweden

Daniel Eriksson
Matteo Bianchi
Olle Kämpe
ResearchOpen Access30 May 2018
Scientific Reports

Volume: 8, P: 1-11
Exploring rare and low-frequency variants in the Saguenay–Lac-Saint-Jean population identified genes associated with asthma and allergy traits

Andréanne Morin
Anne-Marie Madore
Catherine Laprise
ResearchOpen Access11 Sept 2018
European Journal of Human Genetics

Volume: 27, P: 90-101
Contributions of de novo variants to systemic lupus erythematosus

Jonas Carlsson Almlöf
Sara Nystedt
Ann-Christine Syvänen
ResearchOpen Access28 Jul 2020
European Journal of Human Genetics

Volume: 29, P: 184-193
Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Chuan Wang
Annika Ahlford
Johanna K Sandling
ResearchOpen Access19 Dec 2012
European Journal of Human Genetics

Volume: 21, P: 994-999
Novel risk genes for systemic lupus erythematosus predicted by random forest classification

Jonas Carlsson Almlöf
Andrei Alexsson
Ann-Christine Syvänen
ResearchOpen Access24 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Johanna K Sandling
Sophie Garnier
Ann-Christine Syvänen
ResearchOpen Access22 Dec 2010
European Journal of Human Genetics

Volume: 19, P: 479-484
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

Hanna D. Bremer
Nils Landegren
Helene Hansson-Hamlin
ResearchOpen Access19 Mar 2018
Scientific Reports

Volume: 8, P: 1-9

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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system

Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Learning from similarities between vaccine responses and SLE

Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements

Cytokines as therapeutic targets in SLE

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Transancestral mapping and genetic load in systemic lupus erythematosus

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

An epigenome-wide association study of total serum immunoglobulin E concentration

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Variants in BANK1 are associated with lupus nephritis of European ancestry

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts

Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison’s disease in Sweden

Exploring rare and low-frequency variants in the Saguenay–Lac-Saint-Jean population identified genes associated with asthma and allergy traits

Contributions of de novo variants to systemic lupus erythematosus

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Novel risk genes for systemic lupus erythematosus predicted by random forest classification

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

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