Nature Search

Publisher Correction: Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina Slowicka
Ioanna Petta
Geert van Loo
Amendments and Corrections10 Jul 2020
Nature Cancer

Volume: 1, P: 750
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

The oncogenic potential of pks⁺ Escherichia coli depends critically on bacterial adhesion to host epithelial cells mediated by the type 1 pilus adhesin FimH and the F9 pilus adhesin FmlH.

Maude Jans
Magdalena Kolata
Lars Vereecke
Research06 Nov 2024
Nature

Volume: 635, P: 472-480
Zeb2 drives invasive and microbiota-dependent colon carcinoma

Van Loo and colleagues report that loss of the Zeb2 regulator of epithelial-to-mesenchymal transition from the intestinal epithelium leads to inflammation, increased intestinal permeability and colorectal cancer development, which is enhanced by the resident intestinal microbiome.

Karolina Slowicka
Ioanna Petta
Geert van Loo
Research15 Jun 2020
Nature Cancer

Volume: 1, P: 620-634
Author Correction: A20 controls intestinal homeostasis through cell-specific activities

Lars Vereecke
Sara Vieira-Silva
Geert van Loo
Amendments and Corrections31 Mar 2025
Nature Communications

Volume: 16, P: 1
A20 controls intestinal homeostasis through cell-specific activities

Aetiology of colitis is highly complex and incompletely understood. Here the authors show in mouse models that A20 deubiquitinase limits pro-inflammatory cytokine production in myeloid cells while inhibiting proapoptotic response to these cytokines in enterocytes, and that only upon losing both functions intestinal pathologies develop.

Lars Vereecke
Sara Vieira-Silva
Geert van Loo
Research30 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Publisher Correction: Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis

Eric Gracey
Lars Vereecke
Dirk Elewaut
Amendments and Corrections30 Jul 2020
Nature Reviews Rheumatology

Volume: 16, P: 536
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis.

Karolina Slowicka
Inmaculada Serramito-Gómez
Geert van Loo
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-15
Hepatic glutamine synthetase controls N⁵-methylglutamine in homeostasis and cancer

Glutamine synthetase is the only enzyme that synthesizes glutamine in mammals. In vivo metabolomics showed that glutamine synthetase utilizes methylamine to produce N⁵-methylglutamine, whose levels correlate with tumor burden in a β+catenin+mutant liver cancer model.

Victor H. Villar
Maria Francesca Allega
Saverio Tardito
ResearchOpen Access24 Oct 2022
Nature Chemical Biology

Volume: 19, P: 292-300
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

In addition to its role in suppressing MDA5 and PKR activation, ADAR1 is a negative regulator of ZPB1-mediated apoptosis and necroptosis, providing insights into the pathology of Aicardi–Goutières syndrome.

Richard de Reuver
Simon Verdonck
Jonathan Maelfait
Research20 Jul 2022
Nature

Volume: 607, P: 784-789
Ruminococcus on the horizon in arthritic disease

Increasing evidence points to a mechanistic link between gut and joint pathology as the gut contains the largest number of immune cells of any tissue and trillions of commensals that contribute to immune development and homeostasis. New research is putting the role of Ruminococcus gnavus in arthritic disease in the spotlight.

Lars Vereecke
Dirk Elewaut
News & Views17 Aug 2017
Nature Reviews Rheumatology

Volume: 13, P: 574-576
Microbes exploit death-induced nutrient release by gut epithelial cells

Intestinal microorganisms exploit nutrients released by apoptotic gut epithelial cells for growth.

Christopher J. Anderson
Christopher B. Medina
Kodi S. Ravichandran
Research04 Aug 2021
Nature

Volume: 596, P: 262-267
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.

Hannah Van Hove
Liesbet Martens
Kiavash Movahedi
Research06 May 2019
Nature Neuroscience

Volume: 22, P: 1021-1035
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Geert van Loo, Rudi Beyaert, Dirk Elewaut and colleagues report that myeloid-specific deletion of Tnfaip3 in mice causes spontaneous destructive polyarthritis that resembles rheumatoid arthritis. Tnfaip3 encodes the A20 protein, which is involved in negative regulation of NF-κB signaling in response to proinflammatory stimuli.

Mourad Matmati
Peggy Jacques
Geert van Loo
Research14 Aug 2011
Nature Genetics

Volume: 43, P: 908-912
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

This study provides evidence for a critical role of RIPK1 in suppressing caspase-8-mediated cell death and maintaining intestinal homeostasis independently of its kinase activity.

Nozomi Takahashi
Lars Vereecke
Peter Vandenabeele
Research03 Sept 2014
Nature

Volume: 513, P: 95-99
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien Verboom
Christopher J. Anderson
Geert van Loo
ResearchOpen Access19 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-13
Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis

In this article, the authors summarize the latest clinical and basic research on gut inflammation in spondyloarthritis and highlight important questions to address in future research.

Eric Gracey
Lars Vereecke
Dirk Elewaut
Reviews13 Jul 2020
Nature Reviews Rheumatology

Volume: 16, P: 415-433
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion Picard
Satoru Yonekura
Maria Paula Roberti
ResearchOpen Access01 Dec 2020
Cell Death & Differentiation

Volume: 28, P: 1532-1547

Search

Publisher Correction: Zeb2 drives invasive and microbiota-dependent colon carcinoma

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Author Correction: A20 controls intestinal homeostasis through cell-specific activities

A20 controls intestinal homeostasis through cell-specific activities

Publisher Correction: Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Hepatic glutamine synthetase controls N⁵-methylglutamine in homeostasis and cancer

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Ruminococcus on the horizon in arthritic disease

Microbes exploit death-induced nutrient release by gut epithelial cells

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

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