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Showing 1–2 of 2 results
Advanced filters: Author: Lars Wiedmer Clear advanced filters

  • Annunziato, Quan and Donckele et al. identify G3BP2 (Ras–GAP SH3 domain-binding protein 2) as a molecular glue-induced neosubstrate of the CRL4CRBN E3 ubiquitin ligase. The CRBN–glue neosurface uses a molecular surface mimicry mechanism to recruit and degrade G3BP2 in a compound-dependent manner.

    • Stefano Annunziato
    • Chao Quan
    • Georg Petzold
    ResearchOpen Access
    Nature Structural & Molecular Biology
    P: 1-9