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COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation

Common variable immunodeficiency (CVID) is a prevalent primary immunodeficiency characterized by hypogammaglobulinemia, poor antibody responses, and enhanced susceptibility to infection. Here the authors examine CVID patients infected by SARS-CoV-2 and describe broad immune dysregulation, sustained type I IFN responses, altered B/T cell signaling, impaired NK cell differentiation, and persistent inflammasome activation.

Javier Rodríguez-Ubreva
Josep Calafell-Segura
Esteban Ballestar
ResearchOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1-21
Correction: Corrigendum: B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Irene Puga
Montserrat Cols
Andrea Cerutti
Amendments and Corrections21 Jan 2014
Nature Immunology

Volume: 15, P: 205
Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

Andrey Ziyatdinov
Jason Torres
Roberto Tapia-Conyer
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 784-793
Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Andrey Ziyatdinov
Jason Torres
Roberto Tapia-Conyer
Amendments and CorrectionsOpen Access08 Feb 2024
Nature

Volume: 626, P: E18
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Follicular T cells provide help to B cells to elicit antibody responses. Cerutti and colleagues show that neutrophils provide help to marginal-zone B cells that produce T cell–independent antibodies.

Irene Puga
Montserrat Cols
Andrea Cerutti
Research25 Dec 2011
Nature Immunology

Volume: 13, P: 170-180
Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation.

Bence Bago
Marton Kovacs
Balazs Aczel
Research14 Apr 2022
Nature Human Behaviour

Volume: 6, P: 880-895
To which world regions does the valence–dominance model of social perception apply?

Jones et al. examine the generalizability of the valence–dominance model of social judgements of faces in 41 countries across 11 world regions. They find evidence of both generalizability and variation, depending on the analytical method.

Benedict C. Jones
Lisa M. DeBruine
Nicholas A. Coles
Research04 Jan 2021
Nature Human Behaviour

Volume: 5, P: 159-169
Publisher Correction: Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Bence Bago
Marton Kovacs
Balazs Aczel
Amendments and Corrections06 Jun 2022
Nature Human Behaviour

Volume: 6, P: 897-898
Copper single-atoms embedded in 2D graphitic carbon nitride for the CO₂ reduction

Claudio Cometto
Aldo Ugolotti
Gaetano Granozzi
ResearchOpen Access02 Jul 2021
npj 2D Materials and Applications

Volume: 5, P: 1-10
Neuroimmune crosstalk in the pathophysiology of hypertension

Neuroimmune crosstalk has a potential role in the development and maintenance of arterial hypertension. Parati and colleagues discuss the interplay between the bone marrow, microglia and immune mediators, in particular through mechanisms involving cytokines and peptides, such as neuropeptide Y, substance P, angiotensin II and angiotensin-(1–7).

Laura Calvillo
Mariela M. Gironacci
Gianfranco Parati
Reviews20 Mar 2019
Nature Reviews Cardiology

Volume: 16, P: 476-490

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