Nature Search

A genome-wide association analysis reveals new pathogenic pathways in gout

Genome-wide association analysis of gout and urate identifies 148 new loci, implicating biological pathways and prioritizing candidate genes involved in inflammatory processes.

Tanya J. Major
Riku Takei
Tony R. Merriman
Research15 Oct 2024
Nature Genetics

Volume: 56, P: 2392-2406
A united call for gender equity in global health leadership

Catherine Moughalian
Malvikha Manoj
Roopa Dhatt
Correspondence26 Aug 2024
Nature Medicine

Volume: 30, P: 2386-2387
A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)

Impaired awareness of hypoglycaemia (IAH) is a risk for severe hypoglycaemia in insulin treatment of type 1 diabetes (T1D). Here the authors report that a group programme focussing on changing cognitive barriers to avoiding hypoglycaemia (HARPdoc) does not reduce severe hypoglycaemia more than a programme focussing on behaviours (BGAT) in a randomized control trial in adults with T1D and treatment-resistant IAH and severe hypoglycaemia.

Stephanie A. Amiel
Laura Potts
Nicole de Zoysa
ResearchOpen Access28 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Derya R. Shimshek
Laura H. Jacobson
Ulf Neumann
ResearchOpen Access25 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895
Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout

Tanya J. Major
Riku Takei
Tony R. Merriman
Amendments and Corrections05 Nov 2024
Nature Genetics

Volume: 56, P: 2577
The COVIDTrach prospective cohort study on outcomes in 1982 tracheostomised COVID-19 patients during the first and second UK pandemic waves

Matthew Haywood
Gareth Ambler
Andrzej Sladkowski
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
A giant impact as the likely origin of different twins in the Kepler-107 exoplanet system

Kepler-107 b and c have the same radius but, contrary to expectations, the outermost Kepler-107 c is much denser. This difference cannot be explained by photoevaporation by stellar high-energy particle flux and it suggests that Kepler-107 c experienced a giant impact event.

Aldo S. Bonomo
Li Zeng
Chris Watson
Research04 Feb 2019
Nature Astronomy

Volume: 3, P: 416-423
Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat

Lauren R. Finka
Lucia Ripari
Marnie L. Brennan
ResearchOpen Access15 Jul 2022
Scientific Reports

Volume: 12, P: 1-13

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