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Showing 1–3 of 3 results
Advanced filters: Author: Laura Hilditch Clear advanced filters

  • Innate immune evasion is key to evolution of the pandemic lineage of HIV.

    • Lorena Zuliani-Alvarez
    • Morten L. Govasli
    • Greg J. Towers
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 1762-1776

  • Human immunodeficiency virus (HIV)-1 is shown here to depend on the recruitment to the HIV-1 capsid of specific cofactors involved in orchestrating nuclear entry and targeting; when these capsid–cofactor interactions are prevented either by virus mutation, cofactor depletion or pharmacological inhibition of cofactor recruitment, viral DNA can be detected by innate immune sensors.

    • Jane Rasaiyaah
    • Choon Ping Tan
    • Greg J. Towers
    Research
    Nature
    Volume: 503, P: 402-405