Nature Search

Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features

Iacobucci et al. present the single-cell transcriptomic profile of patients with B cell acute lymphoblastic leukemia, report enriched multipotency and develop a multipotency score that is associated with worse survival in pediatric patients.

Ilaria Iacobucci
Andy G. X. Zeng
Charles G. Mullighan
Research27 Jun 2025
Nature Cancer

Volume: 6, P: 1242-1262
Genomic subtyping and therapeutic targeting of acute erythroleukemia

Analysis of genomic and clinical features of acute erythroid leukemia in comparison to other myeloid disorders supports its distinct classification, defines subgroups and suggests therapeutic vulnerabilities.

Ilaria Iacobucci
Ji Wen
Charles G. Mullighan
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 694-704
Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

The Activin-A precursor protein undergoes proteolytic processing by furin and other proteases. Here the authors identify that kallikrein-8 mediates furin-independent cleavage of Activin-A precursor to promote tumor growth in a murine melanoma model.

Manon Bulliard
Katarina Pinjusic
Daniel B. Constam
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-18
The genetic basis and cell of origin of mixed phenotype acute leukaemia

A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.

Thomas B. Alexander
Zhaohui Gu
Charles G. Mullighan
Research12 Sept 2018
Nature

Volume: 562, P: 373-379
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

Genomic and transcriptomic analyses of chronic lymphoproliferative disorder of natural killer cells identifies somatic gain-of-function mutations in the chemokine gene CCL22 with cell-extrinsic effects. Mutations caused biased signaling downstream of the G-protein-coupled receptor for CCL22 and deregulated interactions with the hematopoietic microenvironment.

Constance Baer
Shunsuke Kimura
Charles G. Mullighan
Research05 May 2022
Nature Genetics

Volume: 54, P: 637-648
Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients

Wulf Palinski
Maria Monti
Filomena de Nigris
ResearchOpen Access17 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-13

Search

Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features

Genomic subtyping and therapeutic targeting of acute erythroleukemia

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

The genetic basis and cell of origin of mixed phenotype acute leukaemia

CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients

Search

Quick links

Search

Filter By:

Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features

Genomic subtyping and therapeutic targeting of acute erythroleukemia

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

The genetic basis and cell of origin of mixed phenotype acute leukaemia

CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients

Search

Quick links