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Showing 1–5 of 5 results
Advanced filters: Author: Laura Kristine Holm Clear advanced filters

  • Cetnarowska and co-workers show that transcriptional activation of the PPARG locus, encoding the master regulator of adipogenesis, relies on extensive enhancer crosstalk. Cardiometabolic disease associated SNPs map to key regulatory enhancers.

    • Anna Cetnarowska
    • Mette Hyldahl
    • Susanne Mandrup
    ResearchOpen Access
    Nature Communications
    P: 1-20

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Genomic and transcriptomic analyses of chronic lymphoproliferative disorder of natural killer cells identifies somatic gain-of-function mutations in the chemokine gene CCL22 with cell-extrinsic effects. Mutations caused biased signaling downstream of the G-protein-coupled receptor for CCL22 and deregulated interactions with the hematopoietic microenvironment.

    • Constance Baer
    • Shunsuke Kimura
    • Charles G. Mullighan
    Research
    Nature Genetics
    Volume: 54, P: 637-648

  • This study investigates the dynamics of immunological markers after first SARS-CoV-2 vaccination dose in cohort of healthcare professionals in Denmark. Natural infection was associated with higher antibody responses, and IgG decline varied by age, sex, T-cell response, previous infection, and interval between vaccine doses.

    • Laura Pérez-Alós
    • Jose Juan Almagro Armenteros
    • Peter Garred
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • In this study, the authors investigate immune responses following a third (booster) SARS-CoV-2 vaccination dose in a cohort of healthcare professionals in Denmark. They find stronger immune responses among those with a prior infection, and correlation between lower antibody responses and higher risk of subsequent breakthrough infection.

    • Laura Pérez-Alós
    • Cecilie Bo Hansen
    • Peter Garred
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15