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Showing 1–3 of 3 results
Advanced filters: Author: Laura L. Athman Clear advanced filters

  • Facioscapulohumeral muscular dystrophy is a severe myopathy that is caused by abnormal activation of DUX4, and for which a suitable mouse model does not exist. Here, the authors generate a novel mouse model with titratable expression of DUX4, and show that it recapitulates several features of the human pathology.

    • Darko Bosnakovski
    • Sunny S. K. Chan
    • Michael Kyba
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate treatments a high priority. Heinz Feldmann, Vincent J. Munster and Michael G. Katze and their colleagues now report that treating MERS-CoV-infected rhesus macaques with interferon-α2b and ribavirin reduced virus replication and infection severity, suggesting the potential use of this combination for the clinical treatment of infected humans.

    • Darryl Falzarano
    • Emmie de Wit
    • Heinz Feldmann
    Research
    Nature Medicine
    Volume: 19, P: 1313-1317