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Showing 1–21 of 21 results
Advanced filters: Author: Laura Machesky Clear advanced filters

    • Filippo G. Giancotti
    • Cole M. Haynes
    • Michael Overholtzer
    Comments & Opinion
    Nature Cell Biology
    Volume: 17, P: 839-840

  • Fort et al. identify CYRI as a conserved negative modulator of Scar–WAVE-induced lamellipodia by interacting directly with active Rac1, thereby conferring pseudopod plasticity and dynamics during motility.

    • Loic Fort
    • José Miguel Batista
    • Laura M. Machesky
    Research
    Nature Cell Biology
    Volume: 20, P: 1159-1171

  • Extracellular-matrix remodelling promotes tumour progression and metastasis. Papalazarou et al. demonstrate that mechanosensing affects pancreatic cancer cell migration, metabolism and ultimately metastatic potential by targeting the creatine–phosphagen ATP-recycling system.

    • Vassilis Papalazarou
    • Tong Zhang
    • Laura M. Machesky
    Research
    Nature Metabolism
    Volume: 2, P: 62-80

  • Photoreceptor outer segment abnormalities cause retinitis pigmentosa, a form of blindness. Here, authors show that the disease-associated gene RPGR regulates actin-mediated outer segment turnover through its interaction with the actin severer, cofilin.

    • Roly Megaw
    • Abigail Moye
    • Pleasantine Mill
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • The WAVE regulatory complex is well known as an orchestrator of actin dynamics at the leading edge of migrating cells. A recent study shows how mechanical effects can regulate the WAVE complex and explains the importance of forces generated by actin filaments to control new actin generation at the leading edge.

    • Laura M. Machesky
    • Robert H. Insall
    News & Views
    Nature Cell Biology
    Volume: 23, P: 1111-1112

  • In order to move, cells need to push out protrusions known as lamellipods. These can vary greatly in their shapes, dynamics and contributions to motility, depending on their underlying molecular architecture.

    • Laura M. Machesky
    News & Views
    Nature
    Volume: 417, P: 495-497

  • Cell shape and movement are largely driven by changes in the cytoskeletal protein actin. Bacteria such as Listeria, which subvert a cell's actin system for their own movement within a cell, are used to study those changes. This bacterial propulsion system has now been stripped down to its minimum requirements -- which, it turns out, are actin and a mere three other proteins

    • Laura M. Machesky
    • John A. Cooper
    News & Views
    Nature
    Volume: 401, P: 542-543

  • The processes that regulate melanoblast migration during development are also thought to be involved in melanoma metastasis. Here, Prex1 null mice are shown to have a melanoblast migration defect and, when crossed to a mouse model of melanoma, are resistant to metastasis, suggesting a role for Prex1 in metastatic melanoma.

    • Colin R. Lindsay
    • Samuel Lawn
    • Owen J. Sansom
    Research
    Nature Communications
    Volume: 2, P: 1-9

  • The MRL protein family is emerging as a new connection between signalling, adhesion and cell motility. Two members, lamellipodin and RIAM, can regulate both actin assembly and cell adhesion, which raises many questions about how their interactions with Ena/VASP proteins, Ras-related GTPases and membranes orchestrate these key processes.

    • John A. Legg
    • Laura M. Machesky
    News & Views
    Nature Cell Biology
    Volume: 6, P: 1015-1017

  • Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione production.

    • Laura M. Machesky
    News & Views
    Nature Cell Biology
    Volume: 25, P: 375-376

  • Cell movement is mediated by dynamic networks of actin — monomers of actin polymerize into filaments near the plasma membrane. How are these actin structures organized? Two groups have found that a seven-protein complex, containing the actin-related proteins Arp2 and Arp3, is responsible for initiating and organizing an actin-based dynamic meshwork that forms protrusions at the leading edge of motile cells.

    • Laura M. Machesky
    • Michael Way
    News & Views
    Nature
    Volume: 394, P: 125-126

  • Recent studies have elucidated multiple virulence mechanisms used byCryptococcus spp. to infect, disseminate within and ultimately kill their human host. In this Review, May et al. describe these recent developments in understanding host–fungal interactions, discuss how they affect disease severity and debate current and future therapeutic interventions against cryptococcosis.

    • Robin C. May
    • Neil R.H. Stone
    • Kirsten Nielsen
    Reviews
    Nature Reviews Microbiology
    Volume: 14, P: 106-117