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Showing 1–2 of 2 results
Advanced filters: Author: Laura Merino-Cacho Clear advanced filters

  • Here, the authors describe BioE3, a biotin-based method to discriminate direct substrates of ubiquitin E3 ligases of interest from mere interactors using proximity proteomics. BioE3 responds to chemical treatments, and works with RING- and HECT-type E3s, as well as ubiquitin-likes (e.g., SUMO).

    • Orhi Barroso-Gomila
    • Laura Merino-Cacho
    • James D. Sutherland
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Several proteomic approaches allow the analysis of covalent protein SUMOylation, but it remains challenging to systematically study the consequences of a substrate being modified. Here, the authors combine proximity biotinylation and protein-fragment complementation to identify SUMO-dependent protein interactors.

    • Orhi Barroso-Gomila
    • Fredrik Trulsson
    • James D. Sutherland
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19