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Showing 1–11 of 11 results
Advanced filters: Author: Laura N. Jeffreys Clear advanced filters

  • Photoreceptor proteins utilise biological chromophores to regulate a large range of cellular processes in response to light. Here the authors identify and characterise a sub-family of multi-centre photoreceptors, termed photocobilins, that not only utilise B12 but also contain biliverdin (BV) as an additional chromophore.

    • Shaowei Zhang
    • Laura N. Jeffreys
    • Nigel S. Scrutton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Multiple transcriptome approaches, including single-cell sequencing, demonstrate that escape from X chromosome inactivation is widespread and occasionally variable between cells, chromosomes, and tissues, resulting in sex-biased expression of at least 60 genes and potentially contributing to sex-specific differences in health and disease.

    • Taru Tukiainen
    • Alexandra-Chloé Villani
    • Daniel G. MacArthur
    ResearchOpen Access
    Nature
    Volume: 550, P: 244-248

  • CarH is a bacterial B12-binding photoreceptor involved in transcriptional regulation. Here, the authors provide insights into B12 dynamics and associated cobalt redox changes following light activation. These demonstrate the CarH response integrates light and oxygen sensing.

    • Harshwardhan Poddar
    • Ronald Rios-Santacruz
    • David Leys
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • When judging the pleasantness of a physical touch experienced by someone else, mothers are more likely to ascribe their personal feelings of pleasantness to their own children as compared to the children of others.

    • Louise P. Kirsch
    • Michal Tanzer
    • Aikaterini Fotopoulou
    ResearchOpen Access
    Communications Psychology
    Volume: 1, P: 1-12

  • High-resolution infrared observations of hard-X-ray-selected black holes show an excess of late-stage mergers in obscured luminous black holes compared with inactive galaxies of similar stellar masses and star formation rates.

    • Michael J. Koss
    • Laura Blecha
    • David B. Sanders
    Research
    Nature
    Volume: 563, P: 214-216

  • In response to recommendations to redefine statistical significance to P ≤ 0.005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.

    • Daniel Lakens
    • Federico G. Adolfi
    • Rolf A. Zwaan
    Comments & Opinion
    Nature Human Behaviour
    Volume: 2, P: 168-171

  • Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer. Emerging similarities and contrasts will form the basis for targeted therapies of the future and for repurposing existing therapies by molecular rather than histological similarities of the diseases.

    • Kyle Chang
    • Chad J Creighton
    • Joshua M Stuart
    Comments & OpinionOpen Access
    Nature Genetics
    Volume: 45, P: 1113-1120