Nature Search

Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics

Leah V. Schaffer
Mengzhou Hu
Trey Ideker
Amendments and CorrectionsOpen Access02 Oct 2025
Nature

Volume: 646, P: E16
Protein aggregates caught stalling

Low-complexity protein aggregates are a hallmark of neurodegeneration. High-resolution snapshots of the structure of one such aggregate offer an unprecedented view of how these proteins disrupt crucial cellular functions.

Laura Pontano Vaites
J. Wade Harper
News & Views19 Mar 2018
Nature

Volume: 555, P: 449-451
Multimodal cell maps as a foundation for structural and functional genomics

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paediatric cancer genomes.

Leah V. Schaffer
Mengzhou Hu
Trey Ideker
ResearchOpen Access09 Apr 2025
Nature

Volume: 642, P: 222-231
Covariation MS uncovers a protein that controls cysteine catabolism

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

Haopeng Xiao
Martha Ordonez
Edward T. Chouchani
ResearchOpen Access17 Sept 2025
Nature

Volume: 647, P: 268-276
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples

A set of isobaric labeling reagents called TMTpro enables deep quantitative comparisons of proteome measurements across 16 samples.

Jiaming Li
Jonathan G. Van Vranken
Joao A. Paulo
Research16 Mar 2020
Nature Methods

Volume: 17, P: 399-404
A multi-scale map of cell structure fusing protein images and interactions

Protein immunofluorescence imaging and affinity purification–mass spectrometry are combined to create a unified map of human cell architecture across scales, which the authors call the multi-scale integrated cell (MuSIC).

Yue Qin
Edward L. Huttlin
Trey Ideker
Research24 Nov 2021
Nature

Volume: 600, P: 536-542
Transient commensal clonal interactions can drive tumor metastasis

Cooperative interactions among tumor cells may have important implications for metastasis. Here, the authors examined the spatio-temporal nature of interactions among clonal populations of ovarian carcinoma cells and found that transient interactions cells can promote metastases via commensal interactions.

Suha Naffar-Abu Amara
Hendrik J. Kuiken
Joan S. Brugge
ResearchOpen Access16 Nov 2020
Nature Communications

Volume: 11, P: 1-17
Architecture of the human interactome defines protein communities and disease networks

Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived human protein interaction network so far, termed BioPlex 2.0.

Edward L. Huttlin
Raphael J. Bruckner
J. Wade Harper
Research17 May 2017
Nature

Volume: 545, P: 505-509

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