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Signal Transduction and Targeted Therapy (1)
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Advanced filters: Author: Laura Raccosta Clear advanced filters

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

Sterol metabolism modulates immune responses through liver X receptor activation. Tumors harness this signaling pathway and can escape immunosurveillance by inhibiting dendritic cell migration to tumor-draining lymph nodes.

Eduardo J Villablanca
Laura Raccosta
Vincenzo Russo
Research27 Dec 2009
Nature Medicine

Volume: 16, P: 98-105
LIM-domain-only 4 (LMO4) enhances CD8⁺ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling

Roland C. Schelker
Jessica Fioravanti
Luca Gattinoni
ResearchOpen Access09 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses

Laura Raccosta
Maura Marinozzi
Vincenzo Russo
ResearchOpen Access15 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-21